The brain's response to alcohol varies based on individual preferences, according to new research in rats published in eNeuro.
Not everyone is prone to developing an alcohol use disorder. Some people can drink every day without acquiring a dependence, yet far less drinking may drive another person into addiction. This difference may be explained by how the brain interprets alcohol as a reward. The orbitofrontal cortex (OFC) stores reward value and regulates reward seeking, so OFC activity corresponds to individual preferences for drugs. Its malfunctioning may be involved in drug use disorders.
To see if the same pattern held true for alcohol, Hernandez and Moorman measured the OFC activity of rats while they alternated consuming sugar and alcohol. Neurons in the OFC behaved differently in each rat but correlated with how much alcohol the rat consumed when given free access -- a marker of preference. The OFC in high-drinking rats responded to alcohol in a similar fashion to sugar, a universally rewarding substance to rats. But OFC responses to alcohol were suppressed in low-drinking rats, a sign that they did not find it as rewarding as sugar. If the brains of high-drinking rats find alcohol more rewarding than low-drinking rats, they may have a higher risk for developing a dependence.
Manuscript title: Orbitofrontal Cortex Encodes Preference for Alcohol
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eNeuro is an online, open-access journal published by the Society for Neuroscience. Established in 2014, eNeuro publishes a wide variety of content, including research articles, short reports, reviews, commentaries and opinions.
About The Society for Neuroscience
The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 37,000 members in more than 90 countries and over 130 chapters worldwide.