News Release

Ganoderic acid increases radiosensitivity of cancer cell

Peer-Reviewed Publication

Hefei Institutes of Physical Science, Chinese Academy of Sciences

Ganoderic Acid increases Radiosensitivity of Cancer Cell

image: Schematic diagram of the biochemical events of GAT and ionizing radiation on cells. view more 

Credit: SHAO Changsheng

Recently, the research team led by Prof. KONG Lingtao from Institute of Solid State Physics, Hefei Institutes of Physical Science (HFIPS) prepared a highly active single iron atom catalyst (Fe-ISAs@CN) which can activate H2O2 to generate free radicals, achieving rapid removal of sulfadiazine pollutants in aqueous. The relevant results were published in Journal of Colloid and Interface Science.

Sulfadiazine (SDZ), a kind of synthetic sulfadiazine antibiotic, is widely used in clinical and animal husbandry industries. However, due to its large-scale use and unqualified discharge of wastewater, more and more antibiotic residues are detected in the water environment. These antibiotics are still highly toxic at very low concentrations. Due to the stable chemical structure of sulfadiazine, it is difficult to solve the residual problem with conventional processing technology.

In this research, researchers synthesized the Fe(acac)3@ZIF8 precursor using a solvothermal method, and then calcined at a high temperature of 930? to prepare a dodecahedral Fe-ISAs@CN catalyst with uniform morphology and good dispersion. Its rough surface and hollow structure provide a large specific surface area and expose a large number of adsorption sites.

The results of degradation experiments showed that 0.1g/L Fe-ISAs@CN could remove 91% of 20 mg/L SDZ within 60 minutes under acid pH conditions.

"We looked into the mechanism, and found those active sites could rapidly activate H2O2 in a short time," said YANG Wu, leading scientist of the research, "It produced a large number of active substances with stronger oxidizing energy, and the adsorption site could adsorb SDZ to assist the degradation process."

The result proved the rapid degradation of sulfadiazine in the restricted range. Combined with the LC-MS data, they proposed the possible degradation pathways. After five cycles, the removal rate of sulfadiazine was still greater than 80%, and the loss of iron in the catalyst was rather small, indicating good stability of the material.

This work breaks through the traditional Fenton's stringent pH restrictions and provides new ideas for the rapid and deep removal of micro-pollutants in water by nanomaterials.


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