People at high risk of a heart attack in adulthood could be spotted much earlier in life with a one-off DNA test, according to new research part-funded by the British Heart Foundation and published today in the Journal of the American College of Cardiology.
An international team led by researchers from the University of Leicester, University of Cambridge and the Baker Heart and Diabetes Institute in Australia used UK Biobank data to develop and test a powerful scoring system, called a Genomic Risk Score (GRS) which can identify people who are at risk of developing coronary heart disease prematurely because of their genetics.
Genetic factors have long been known to be major contributors of someone's risk of developing coronary heart disease - the leading cause of heart attacks. Currently to identify those at risk doctors use scores based on lifestyle and clinical conditions associated with coronary heart disease such as cholesterol level, blood pressure, diabetes and smoking. But these scores are imprecise, age-dependent and miss a large proportion of people who appear 'healthy', but will still develop the disease.
The 'big-data' GRS technique takes into account 1.7 million genetic variants in a person's DNA to calculate their underlying genetic risk for coronary heart disease.
The team analysed genomic data of nearly half a million people from the UK Biobank research project aged between 40-69 years. This included over 22,000 people who had coronary heart disease. The GRS was better at predicting someone's risk of developing heart disease than each of the classic risk factors for coronary heart disease alone. The ability of the GRS to predict coronary heart disease was also largely independent of these known risk factors. This showed that the genes which increase the risk of coronary heart disease don't simply work by elevating blood pressure or cholesterol, for example.
People with a genomic risk score in the top 20 per cent of the population were over four-times more likely to develop coronary heart disease than someone with a genomic risk score in the bottom 20 per cent.
In fact, men who appeared healthy by current NHS health check standards but had a high GRS were just as likely to develop coronary heart disease as someone with a low GRS and two conventional risk factors such as high cholesterol or high blood pressure.
These findings help to explain why people with healthy lifestyles and no conventional risk factors can still be struck by a devastating heart attack.
Crucially, the GRS can be measured at any age including childhood as your DNA does not change. This means that those at high risk can be identified much earlier than is possible through current methods and can be targeted for prevention with lifestyle changes and, where necessary, medicines. The GRS is also a one-time test and with the cost of genotyping to calculate the GRS now less than £40 GBP ($50 USD) it is within the capability of many health services to provide.
Senior author Professor Sir Nilesh Samani, Professor of Cardiology at the University of Leicester and Medical Director at the British Heart Foundation said:
"At the moment we assess people for their risk of coronary heart disease in their 40's through NHS health checks. But we know this is imprecise and also that coronary heart disease starts much earlier, several decades before symptoms develop. Therefore if we are going to do true prevention, we need to identify those at increased risk much earlier.
"This study shows that the GRS can now identify such individuals. Applying it could provide a most cost effective way of preventing the enormous burden of coronary heart disease, by helping doctors select patients who would most benefit from interventions and avoiding unnecessary screening and treatments for those unlikely to benefit."
Lead author Dr Michael Inouye, of the Baker Heart and Diabetes Institute and University of Cambridge said:
"The completion of the first human genome was only 15 years ago. Today, the combination of data science and massive-scale genomic cohorts has now greatly expanded the potential of healthcare. "While genetics is not destiny for coronary heart disease, advances in genomic prediction have brought the long history of heart disease risk screening to a critical juncture, where we may now be able to predict, plan for, and possibly avoid a disease with substantial morbidity and mortality."
This study was supported by funding from the British Heart Foundation, National Health and Medical Research Council (NHMRC, Australia), the Victorian Government and the Australian Heart Foundation.
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Notes to editors
1. Coronary heart disease (CHD)
Coronary heart disease is the most common type of heart and circulatory disease. It occurs when coronary arteries become narrowed by a build-up of atheroma, a fatty material within their walls. The pain or discomfort felt from such narrowing is called angina and if a blockage occurs it can cause a myocardial infarction (heart attack).
- CHD is the leading cause of death worldwide
- CHD is responsible for over 66,000 deaths in the UK each year, an average of 180 people each day, or one death around every eight minutes.
- Nearly 22,000 people under the age of 75 in the UK die from CHD each year.
- CHD kills more than twice as many women in the UK as breast cancer.
- Coronary heart disease is the most common cause of heart attack. In the UK there are 188,000 hospital visits each year due to heart attacks: that's one every three minutes.
- Healthcare costs relating to heart and circulatory diseases are estimated at £9 billion each year.
- CVD's cost to the UK economy (including premature death, disability and informal costs) is estimated to be £19 billion each year.
British Heart Foundation
Heart and circulatory diseases kill 1 in 4 people in the UK. For over 50 years we've pioneered research that's transformed the lives of people living with heart and circulatory conditions. Our work has been central to the discoveries of vital treatments that are changing the fight against heart disease. But so many people still need our help. From babies born with life-threatening heart problems to the many Mums, Dads and Grandparents who survive a heart attack and endure the daily battles of heart failure. Every pound raised, minute of your time and donation to our shops will help make a difference to people's lives.
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Journal of the American College of Cardiology