News Release

标靶KRAS用于可能的癌症疗法

Peer-Reviewed Publication

Proceedings of the National Academy of Sciences

科研人员描述了一种KRAS抑制剂的特征，KRAS是一种细胞信号传导酶，它的突变驱动着一批癌症；这种抑制剂BI-2852以高亲和力与活性和非活性形式的KRAS构成浅结合口袋，此前这种浅结合口袋被认为无成药性，并且在实验室化验中减少了具有突变的KARS基因的细胞的增殖，这组作者说，这为用于癌症疗法的强效特异性RAS抑制剂的开发铺平了道路。

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Journal

Proceedings of the National Academy of Sciences

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