News Release

Study examines prevalence of rheumatic heart disease in developing country

Peer-Reviewed Publication

JAMA Network

Thomas Pilgrim, M.D., of Bern University Hospital, Bern, Switzerland, and colleagues conducted a study to determine the prevalence and incidence of clinically silent and manifest rheumatic heart disease in Eastern Nepal. The study was published online by JAMA Cardiology.

Three in 4 children grow up in parts of the world where rheumatic heart disease (RHD) is endemic. Nearly eradicated in high-income countries, RHD ranks among the important noncommunicable diseases in low- and middle­ income countries. It is a sentinel of social inequality and a physical manifestation of poverty and continues to be a substantial health care challenge in less privileged regions of the world. This study included 5,178 children, 5 to 15 years of age, from Eastern Nepal. A focused medical history was followed by a brief physical examination. Cardiac auscultation (listening to the heart with a stethoscope) and transthoracic echocardiography were performed by 2 independent physicians.

The prevalence of borderline or definite rheumatic heart disease was 10.2 per 1,000 children and increased with advancing age from 5.5 per 1,000 children 5 years of age to 16.0 in children 15 years of age, whereas the average incidence remained stable at 1.1 per 1,000 children per year. Children with rheumatic heart disease were older than children without rheumatic heart disease and more often female. Silent disease (n = 44) was 5 times more common than manifest disease (n = 9).

"Early detection of silent disease may help prevent progression to severe valvular damage," the authors write.


(JAMA Cardiology. Published online March 2, 2016; doi:10.1001/jamacardio.2015.0292. This study is available pre-embargo at the For The Media website.)

Editor's Note: The study was funded by research grants from the UBS Optimus Foundation and the Foundation Coeur de la Tour from Switzerland. All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

Note: An accompanying commentary, "Screening for Rheumatic Heart Disease in Eastern Nepal," by Bongani M. Mayosi, D.Phil., F.C.P.(S.A.), of Groote Schuur Hospital and University of Cape Town, South Africa, is available pre-embargo at the For The Media website.

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