News Release

Research unlocks new information about reading through visual dictionary in the brain

Peer-Reviewed Publication

University of Texas Health Science Center at Houston

Tandon, University of Texas Health Science Center at Houston

image: Nitin Tandon, MD, and his research team identified a crucial region in the temporal lobe which appears to act as the brain's visual dictionary. view more 

Credit: James LaCombe

The uniquely human ability to read is the cornerstone of modern civilization, yet very little is understood about the effortless ability to derive meaning from written words. Scientists at The University of Texas Health Science Center at Houston (UTHealth) have now identified a crucial region in the temporal lobe, know as the mid-fusiform cortex, which appears to act as the brain's visual dictionary. While reading, the ability of the human brain to distinguish between a real word such as "lemur" and a made-up word like "urmle" appears to lie in the way that region processes information.

These findings were published today in Nature Human Behavior.

"How much the mid-fusiform responds to a word and how quickly it can distinguish between a real and made-up word is highly dependent on how frequently the real word is encountered in everyday language," said Nitin Tandon, MD, senior author, professor and vice chair in the Vivian L. Smith Department of Neurosurgery at McGovern Medical School at UTHealth. "So short, common words like 'say' can be identified quickly but long, infrequent words like 'murmurings' take longer to be identified as real words."

For the study, Nitin Tandon and postdoctoral fellow Oscar Woolnough, PhD, the lead author, used recordings from patients who had electrodes temporarily placed in their brains while undergoing treatment for epilepsy. These recordings were then used to create a visual representation of the early neural processing of written words.

They found that this region, which has been overlooked in many previous studies of reading, compares incoming strings of letters encountered while reading with stored patterns of learned words. After words are identified in this area of the brain, this information is spread to other visual-processing regions of the brain.

"Since word frequency is one of the main factors that determines how fast people can read, it is likely that the mid-fusiform acts as the bottleneck to reading speed," Tandon said. "We showed that if we temporarily disrupt activity in the mid-fusiform cortex using briefly applied electrical pulses, it causes a temporary inability to read, a dyslexia, but doesn't disrupt other language functions like naming visual objects or understanding speech."

Tandon said the study serves to improve understanding of how people read and can help people with reading disorders such as dyslexia, the most common learning disability.


Tandon is co-director of the Texas Institute for Restorative Neurotechnologies at UTHealth, faculty in UTHealth Neurosciences and MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, and an attending physician at Memorial Hermann-Texas Medical Center. UTHealth co-authors were Patrick S. Rollo, research associate, and Kiefer J. Forseth, an MD/PhD student at MD Anderson UTHealth Graduate School.

Other co-authors were from the University of Bucharest, Romania; Universite Paris-Sud and Universite Paris-Saclay, France; Johns Hopkins Medical Center, Baltimore; Rice University, Houston; and College de France, Paris.

The study was funded by the National Institute of Neurological Disorders and Stroke and the National Institute on Deafness and Other Communication Disorders, part of the National Institutes of Health, via the BRAIN Initiative (grant NS098981).

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