ORLANDO, Fla. – New research shows obese children with asthma may mistake symptoms of breathlessness for loss of asthma control leading to high and unnecessary use of rescue medications. The study was published online in the Journal of Allergy and Clinical Immunology (JACI), the official scientific journal of the American Association of Allergy, Asthma and Immunology.
"Obese children with asthma need to develop a greater understanding of the distinct feeling of breathlessness in order to avoid not just unnecessary medication use, but also the anxiety, reduced quality of life and health care utilization that come along with this misunderstood symptom," said Jason Lang, MD, MPH, a physician and researcher in the Division of Pulmonary Medicine at Nemours Children's Hospital in Orlando, Fla. "Alleviating this overuse of rescue medications could likely also lessen other symptoms obese children with asthma are impacted by, including most notably acid reflux."
Researchers, led by Lang, reviewed the lung function, treatment uses, symptom patterns, healthcare utilization, quality of life and caregiver perceptions of asthma-related quality of life in overweight/obese children with asthma (BMI ≥ 85th percentile) and lean counterparts (BMI 20-65th percentile). In total 58 children participated in the study's three clinical visits.
Both groups displayed similar lung function and controller therapy. However, obese children with asthma experienced and reported symptoms differently compared to lean children, noting symptoms of shortness of breath instead of cough, and three times greater use of self-medication with short-acting Beta-agonist (SABA) medications. These children also had lower asthma-related quality of life and greater gastrointestinal symptoms reported by GERD score.
Researchers note that much of the problematic nature of asthma among obese children with early-onset, allergic asthma may stem in part from heightened airflow perception and GERD symptoms, leading to a sensation of breathlessness. Additionally, high SABA use in this group has been previously shown to reduce lower esophageal sphincter tone, perpetuating a cycle of GERD, chest symptoms and more SABA use.
The results have clinical implications for overweight/obese asthmatic children with excessive breathlessness and rescue medication use. Respiratory physicians treating these children should consider weight loss or other alternative self-management plans to improve GERD, asthma-related symptoms and medication utilization.
"This research helps define how overweight and obesity affect the patterns and severity of asthma symptoms in children," said Lang. "We hope to use this information to improve self-management and health care utilization for this critical patient population."
Nemours is an internationally recognized children's health system that owns and operates the Nemours/Alfred I. duPont Hospital for Children in Wilmington, DE, and Nemours Children's Hospital in Orlando, FL, along with major pediatric specialty clinics, primary and urgent care in Delaware, Florida, Pennsylvania and New Jersey.
Established as The Nemours Foundation through the legacy and philanthropy of Alfred I. duPont, Nemours offers pediatric clinical care, research, education, advocacy and prevention programs to all families in the communities it serves.
Journal of Allergy and Clinical Immunology