News Release

When drug treatment for social anxiety is insufficient

TALK THERAPY effectively works in the long run

Peer-Reviewed Publication

University of Miyazaki

Video Abstract (Yoshinaga et al., 2019)

video: A Japanese study group clarified that cognitive therapy maintained its effects more than a year after the end of therapy for patients with a social anxiety disorder even for those who did not respond to antidepressant drugs. The study was published in the journal Psychotherapy and Psychosomatics on May 23, 2019 (Yoshinaga et al., 2019 [doi: 10.1159/000500108,]). view more 


MIYAZAKI, JAPAN-- A Japanese study group clarified that cognitive therapy* maintained its effects more than a year after the end of therapy for patients with a social anxiety disorder (SAD) even for those who did not respond to antidepressant drugs. The study was published online in the journal Psychotherapy and Psychosomatics* on May 23, 2019.

The experiment was led by two experts on cognitive therapy in Japan, Dr. Naoki Yoshinaga, lecturer at University of Miyazaki, and Dr. Eiji Shimizu, professor at Chiba University. Since 2011, they have applied cognitive therapy, which is a Western origin psychological therapy, for patients with SAD in Japan. SAD, also known as social phobia, is a mental disorder characterized by a significant amount of anxiety or fear in social situations, such as talking in front of many people or speaking with strangers, causing considerable distress and functional disability in daily life. SAD is one of the most prevalent mental disorders, typically has early onset, and follows a chronic course because of the low natural recovery rate. SAD has caused a large social economic burden in many countries; according to the prevalence-based study in Japan, the estimate of annual economic loss exceeded 1 trillion yen (about 10 billion USD).

Although antidepressants are an effective treatment commonly used for SAD, some patients fail to remit following these drugs. However, no standard approach has been established for treating such patients. In 2016, Yoshinaga and Shimizu's study group conducted a clinical trial and reported short-term effectiveness of cognitive therapy for patients with SAD who were refractory to antidepressants (Yoshinaga et al., 2016). However, it was still unknown whether the patients could maintain cognitive therapy's effect in the long run.

In this time, they demonstrated that, in refractory patients who received 16-weeks of cognitive therapy, a substantial improvement in social anxiety symptoms occurred during the intervention period, and these improvements were well-maintained until the end of the one-year follow-up. At the one-year follow-up assessment, 85.7% (18/21) of patients were judged to be responsive to the treatment, and 57.1% (12/21) met the remission criteria.

Yoshinaga says, "People suffering from SAD could benefit not only from drug treatment but also from psychological treatment. In particular, cognitive therapy can be of help for them to overcome their problems. Even if drug treatment doesn't work, don't give up hope. Try to receive another psychological treatment, such as cognitive therapy, and continue your treatment with patience." As SAD is a hidden disorder, Shimizu added, "Unfortunately, many patients are not in treatment. SAD is more than just shyness. If you have been having severe distress, avoiding certain social situations, and thus having difficulty in your daily life due to social anxiety, it's time to seek treatment."

Yoshinaga and his Japanese group are currently working with David Clark and Graham Thew from the University of Oxford to develop a Japanese version of an internet-based cognitive therapy program for social anxiety disorder that has shown high efficacy in both the UK and Hong Kong. They are aiming to make progress towards the effective global dissemination of this treatment.



(1) Yoshinaga N., Matsuki S., Niitsu T., Sato Y., Tanaka M., Ibuki H., Takanashi R., Ohshiro K., Ohshima F., Asano K., Kobori O., Yoshimura K., Hirano Y., Sawaguchi K., Koshizaka M., Hanaoka H., Nakagawa A., Nakazato M., Iyo M., Shimizu E. (2016) "Cognitive Behavioral Therapy for Patients with Social Anxiety Disorder Who Remain Symptomatic following Antidepressant Treatment: A Randomized, Assessor-Blinded, Controlled Trial", Psychotherapy and Psychosomatics. Vol. 85, pp. 208-217 [doi: 10.1159/000444221] ,

(2) Yoshinaga N., Kubota K., Yoshimura K., Takanashi R., Ishida Y., Iyo M., Fukuda T., Shimizu E. (2019), "Long-Term Effectiveness of Cognitive Therapy for Refractory Social Anxiety Disorder: One-Year Follow-Up of a Randomized Controlled Trial", Psychotherapy and Psychosomatics. [doi: 10.1159/000500108],


*Psychotherapy and Psychosomatics-- is an official journal of the International College of Psychosomatic Medicine (ICPM) and the International Federation for Psychotherapy (IFP), and is one of the top journals in the psychiatric field.

*Cognitive therapy for SAD-- is a psychological therapy that focuses on how thoughts affect feelings and behaviors. Patients are guided to identify the negative thoughts they experience in social situations and understand how these affect how they feel and behave. Patients are then encouraged to test out such thoughts using various techniques (e.g. role-play, video-feedback, behavioral experiments) both inside and outside of the session room. The idea with cognitive therapy is to address the factors that maintain social anxiety, and help patients learn that their feared concerns are much less likely to happen than they expect. The aim is for patients to apply these techniques and become their own therapist, meaning they can enjoy social interactions more and are able to be themselves more fully.


Naoki Yoshinaga
Organization for Promotion of Tenure Track,
University of Miyazaki, Japan

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