News Release

Even if severe allergic reaction is in doubt, epinephrine should be used

Experts agree it's best to use epinephrine in all emergency situations

Peer-Reviewed Publication

American College of Allergy, Asthma, and Immunology

ARLINGTON HEIGHTS, Ill. (August 6, 2015) - There are times when emergency physicians can't be 100 percent sure a person is suffering from a severe allergic reaction, known as anaphylaxis, and may hesitate to use epinephrine. A new article says when in doubt - administer the epinephrine.

An article in the Annals of Allergy, Asthma and Immunology, the scientific publication of the American College of Allergy, Asthma and Immunology (ACAAI), highlights recommendations from a panel discussion among allergists and emergency physicians. The panel of experts examined barriers to emergency care for anaphylaxis, and discussed ways to encourage appropriate prompt treatment, including the use of epinephrine for all severe allergic reactions.

"Our emergency medicine colleagues told us that if patients don't fit established guidelines for anaphylaxis, there may be a reluctance in the emergency room to treat with epinephrine," said allergist Stanley Fineman, MD, ACAAI past president, and chair of the panel. "Because epinephrine is the first line of defense in treating anaphylaxis, the panel agreed it should be used - even if a patient's reaction may not meet all the established criteria. The consequences for not using epinephrine when it's needed are much more severe than using it when it might not be necessary."

The panel also agreed that epinephrine should be given to patients at risk of an anaphylactic reaction based on a) a previous severe reaction or b) those who have had a known or suspected exposure to their allergic trigger with or without the development of symptoms.

"We want emergency medical personnel, as well as people who have had, or are at risk for having severe allergic reactions to know there is no substitute for epinephrine as the most important tool for combatting anaphylaxis," said allergist Paul Dowling, MD, ACAAI member and panelist. "Antihistamines and corticosteroids should not be given instead of epinephrine because they don't work fast enough."

The other crucial message highlighted by the panel is that anyone seen for anaphylaxis in the emergency room needs to be referred to an allergist to schedule a follow up visit. Allergists provide the most comprehensive follow-up care and guidance for severe allergic reactions.


For more information about treatment of anaphylaxis and to locate an allergist in your area, visit


The ACAAI is a professional medical organization of more than 6,000 allergists-immunologists and allied health professionals, headquartered in Arlington Heights, Ill. The College fosters a culture of collaboration and congeniality in which its members work together and with others toward the common goals of patient care, education, advocacy and research. ACAAI allergists are board-certified physicians trained to diagnose allergies and asthma, administer immunotherapy, and provide patients with the best treatment outcomes. For more information and to find relief, visit Join us on Facebook, Pinterest and Twitter.

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