image: Intervention for prevention. Phases of intervention to reduce HIV transmission and spread emphasize the need for prevention efforts beginning with any sexual coupling in which one individual is HIV-seropositive and transmits to an uninfected partner. (A) Relative risk of infection from a seropositve insertive partner for the cervicovaginal and colorectal compartments are depicted with different sized boxes. Lighter shaded replicates fanning out underneath are meant to reflect multiple transmissions and subsequent infections from the primary insertive partner. (B) Amplification of HIV transmission and infection from a representative index coupling to within higher–sexually active cohorts to the local/regional/national levels with global ramifications shown. At each level, education, test-and-treat, and biological or behavioral interventions (prevention) can be applied to curb the epidemic. This image is figure 1 from the Perspective. This image relates to an article that appeared in the April 6, 2011, issue of Science Translational Medicine, published by AAAS. The Perspective, by Dr. Peter Anton of the David Geffen School of Medicine, University of California, Los Angeles in Los Angeles, Calif., and colleagues, was titled, “HIV Transmission: Time for Translational Studies to Bridge the Gap.” view more
Credit: Image: C. Bickel/<i>Science</i> © 2011 AAAS