News Release

Per- and polyfluoroalkyl substances (PFAS)

New opinion from the European Food Safety Authority

Peer-Reviewed Publication

BfR Federal Institute for Risk Assessment

As early as December 2018, EFSA published a re-evaluation of health risks arising from the presence of certain PFAS in food and derived significantly lower guidance values for two compounds, perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) than before.

In its recent opinion, EFSA has now derived a tolerable weekly intake (TW I) for the sum of four PFAS, namely PFOA, PFOS, perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) of 4.4 nanograms (ng) per kilogram (kg) of body weight per week. This value indicates the amount of a substance that can be ingested weekly over a lifetime with no appreciable health risk.

The TWI derivation is based on observations from epidemiological studies that indicate that these PFAS affect the immune system. In these studies, it was observed that children who had higher concentrations of certain PFAS in their blood serum produced fewer antibodies after having common vaccinations.

Consumers can barely influence their intake of PFAS. The primary sources for human exposure are food and drinking water.

The BfR will examine EFSA's opinion.

The BfR has updated its FAQs on PFAS based on the new EFSA opinion:


More information on the BfR website on perfluorinated and polyfluoroalkyl substances (PFAS):

About the BfR

The German Federal Institute for Risk Assessment (BfR) is a scientifically independent institution within the portfolio of the Federal Ministry of Food and Agriculture (BMEL) in Germany. It advises the German federal government and German federal states ("Laender") on questions of food, chemical and product safety. The BfR conducts its own research on topics that are closely linked to its assessment tasks.

This text version is a translation of the original German text which is the only legally binding version.

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