News Release

来自真菌的阿片类镇痛药

Peer-Reviewed Publication

Proceedings of the National Academy of Sciences

Bilorphin (Red) Bound to the mu Opioid Receptor (Wheat) in Membrane

image: Bilorphin (red) bound to the mu opioid receptor (wheat) in membrane. view more 

Credit: Image courtesy of Richard B. Sessions

科研人员报告说,从澳大利亚的一个河口发现的一种青霉菌真菌物种分离出的3个肽含有的天然形成的氨基酸表现出了在自然界的氨基酸中罕见的镜像结构;根据这些肽的结构,这组科研人员开发出了bilorphin和bilactorphin,这是作用于阿片受体但是通过不同于传统阿片类药物的一个信号传导路径的镇痛药,这提示这些镇痛药可能为开发有效管理疼痛而几乎没有副作用的药物铺平道路。

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