image: SRS imaging during simulated brain tumor surgery on mouse brain. SRS images were obtained on live mice during various stages of a simulated tumor removal. The cartoons on the right show the depth of imaging. (A) In a tumor located beneath the cortical surface, there is no obvious abnormality in SRS (left) or bright-field images (middle) when imaging the cortical surface. (B) After a portion of the cortex has been removed, the tumor is revealed. Blood was present on the dissected surface, but did not adversely affect the distinction from tumor-infiltrated regions from non-infiltrated regions. (C) As dissection was carried deep past the tumor, the normal appearance of white matter and cortex was again visible. This image relates to a paper that appeared in the September 4, 2013, issue of Science Translational Medicine, published by AAAS. The paper, by M. Ji at Harvard University in Cambridge, Mass., and colleagues was titled, "Rapid, Label-Free Detection of Brain Tumors With Stimulated Raman Scattering Microscopy." view more
Credit: Image courtesy of <i>Science Translational Medicine</i>/AAAS