UK and European research collaborations in cancer research have received a vote of confidence by three major cancer charities, with an announcement today of approximately £30 million into six international projects.
Cancer Research UK is partnering with two of Europe's leading cancer research charities, AIRC (Associazione Italiana per la Ricerca sul Cancro) and FC AECC (Asociación Española Contra el Cáncer), to invest in six international collaborations, which are aimed at accelerating progress in translational research.
Scientists in the 5-year funded Accelerator Awards* projects will investigate the potential of immunotherapies in treating liver cancer; develop manufacturing methods for CAR-T cell production; track cancer cell evolution; investigate drug resistance in blood cancers; devise a blood test for advanced prostate cancer and find new routes for personalising blood cancer treatment.
As the UK and EU work to form a new relationship after Brexit, the awards are an example of how funding organisations are seeking to continue to collaborate post-Brexit to drive research forward.
Dr Iain Foulkes, executive director of research and innovation at Cancer Research UK, said: "No single organisation or country is going to beat cancer on its own. Research must be prioritised as the UK builds a new relationship with the EU, as much-needed breakthroughs in treatment are dependent on collective action from the international research community.
"Our Accelerator Award funding will lay the groundwork for a Europe and UK research pipeline, boosting our life sciences industry, and ensuring basic biological research translates into new innovative treatments in future."
Each collaboration is aiming to deepen our understanding of cancer and bring us closer to new treatments, making use of the expertise and diverse technologies of the different partner organisations. UK scientists are leading two of the funded programmes, Italian scientists are leading three, and one by a Spanish researcher.
The scope of these awards brings together world-class researchers who would not have previously been able to work together without this funding available. A number of the grants are also focused on training the next generation of early career scientists and clinicians so that the expertise is developed to carry this research forward.
Federico Caligaris Cappio, AIRC scientific director, said: "Cancer research must innovate relentlessly to understand and deal with the complexity of cancer. This requires more investment, coordinated interdisciplinary research and international collaborations, because cancer doesn't know borders, and research has to overcome them. The partnership with Cancer Research UK and FC AECC has allowed us to fund collaborative projects that promote the development of international networks and the creation of new research tools that could not be done independently at the national level."
Isabel Orbe, general director of the FC AECC, said: "A global collaboration is needed to accelerate results in cancer research. This charity partnership will provide tools to support researchers in an international framework, helping them to create multidisciplinary networks and support the research of new unexplored areas. Moreover, this call looks to improve cancer research in a global manner and with a clear focus on the patients, with the final aim of defeating cancer."
Accelerator Award projects include:
- HUNTER: Hepatocellular Carcinoma Expediter Network - Newcastle University will be leading a project of around £5 million to establish a European and UK network of clinicians and scientists specialising in hepatocellular carcinoma (HCC) - the most common primary liver cancer in adults. The aim will be to understand the immune environment in liver cancer and whether immunotherapies might be effective at treating this disease.
- Innovative CAR Therapy Platform (INCAR) - The University of Milan-Bicocca will be leading a project of around £4.5 million to support research into CAR T-cell therapy, which is where immune cells are 'edited' so that they are more able to target and destroy tumour cells. The team aim to make these therapies more accessible and affordable through developing manufacturing methods and providing recommendations for CAR T-cell immunotherapy development, which could be applied to a broad range of cancer types.
- Single cell cancer evolution in the clinic - Researchers at Fondazione Centro San Raffaele, Functional Genomics of Cancer Unit, will lead on project with around £4.8 million funding to track cancer cell evolution in organoids, clusters of cells that behave similarly to cells in human organs. Their findings will be used to learn more about drug resistance, and to predict optimal treatment options for relapsed cancer patients.
- Early detection and intervention: Understanding the mechanisms of transformation and hidden resistance of incurable haematological malignancies - The Clinica Universidad de Navarra is leading on a project of around £4.8 million to investigate blood cancers. The team will seek to uncover the mechanisms of initial tumour resistance to drugs and identify new treatment opportunities for the disease.
- Multi-modal clinical testing of prostate cancer patients plasma - The University of Trento, Centre for Integrative Biology (CIBIO), are leading on a project worth around £5 million to develop a blood test for advanced prostate cancer treatment selection. The team's work will look to develop a test ready for clinical studies that will stratify patients into personalised treatment arms.
- ACRCelerate: Colorectal Cancer Stratified Medicine Network - The Cancer Research UK Beatson Institute in Glasgow will lead on a project with up to £5 million funding to find new routes for personalised bowel cancer treatment. The team will be looking to identify new targets so that patients can be stratified into different treatment groups, which may lower the risks for patients in clinical trials. These methods will also help to reduce the level of animal research required.
For media enquiries contact Carl Alexander in the Cancer Research UK press office on 020 3469 8882 or, out of hours, on 07050 264 059.
Notes to editor:
- Accelerator Awards webpage: https://www.cancerresearchuk.org/funding-for-researchers/our-funding-schemes/accelerator-award
About Cancer Research UK
- Cancer Research UK is the world's leading cancer charity dedicated to saving lives through research.
- Cancer Research UK's pioneering work into the prevention, diagnosis and treatment of cancer has helped save millions of lives.
- Cancer Research UK receives no funding from the UK government for its life-saving research. Every step it makes towards beating cancer relies on vital donations from the public.
- Cancer Research UK has been at the heart of the progress that has already seen survival in the UK double in the last 40 years.
- Today, 2 in 4 people survive their cancer for at least 10 years. Cancer Research UK's ambition is to accelerate progress so that by 2034, 3 in 4 people will survive their cancer for at least 10 years.
- Cancer Research UK supports research into all aspects of cancer through the work of over 4,000 scientists, doctors and nurses.
- Together with its partners and supporters, Cancer Research UK's vision is to bring forward the day when all cancers are cured.
For further information about Cancer Research UK's work or to find out how to support the charity, please call 0300 123 1022 or visit http://www.cancerresearchuk.org. Follow us on Twitter and Facebook.
The Italian Association for Cancer Research was founded in 1965, the first Italian non-profit association to support scientific research, entirely supported by donations from individuals.
AIRC is today the main private cancer research charity in Italy, thanks to its 4.5 million supporters. In little more than 50 years, together with its Foundation, AIRC has distributed over 1.3 billion euro to cancer research (data updated to 1 January 2018). In 2018 alone, AIRC has made available to the Italian scientific community more than 118 million euro to support 584 research projects, 66 scholarships and other special programs. About 5,000 researchers - a real army of scientists, 63% women, 54% of under 40 - are working to make cancer ever more curable, in laboratories at universities, hospitals and research institutions all over Italy, mainly in public facilities, with a tangible benefit for the country's research and health systems. In addition to supporting innovative scientific projects, AIRC disseminates scientific information and promotes the culture of prevention among the lay community.
About FC AECC
The Spanish Association Against Cancer, AECC, is a private non-profit organization which has been working since 1953 to fight cancer. The AECC is integrated by patients, families, volunteers and professionals who work together to prevent, raise awareness, accompany cancer patients and their families and fund cancer research projects that will enable better diagnosis and treatment of cancer.