WASHINGTON -- Veterans who participated in a series of tests during the 1960s known as Project SHAD (Shipboard Hazard and Defense) show no significant increase in adverse health outcomes, specific causes of death, or death rates compared with a similar group of veterans who were not involved in the tests, says a new report from a committee of the National Academies of Sciences, Engineering, and Medicine. The congressionally mandated report builds on a 2007 Institute of Medicine report, which also found no consistent, specific patterns of poorer health among SHAD veterans.
In addition, although the 2007 report suggested an increased risk of death from heart disease for SHAD veterans, the committee that wrote the new report found no such increased risk after analyzing cause-of-death data from seven additional years of follow-up.
Project SHAD was a series of tests conducted by the U.S. Department of Defense during the 1960s to evaluate the vulnerabilities of U.S. Navy ships to chemical and biological warfare agents. Many of the substances used in the tests were simulants and tracers presumed to be innocuous such as Bacillus globigii and sodium fluorescein, but some tests involved active agents such as infectious bacteria Coxiella burnetii, which causes Q fever, and the nerve agents sarin and VX. Approximately 5,900 veterans, primarily from the Navy and Marine Corps, were involved in the testing, which were classified as "secret" or "top secret."
In 2010, Congress asked the Academies for an additional study on the potential long-term health effects for SHAD veterans. The committee that conducted the new study evaluated causes of death of veterans in the study population since the 1960s and the diagnoses assigned at hospital and outpatient visits in data from the VA health system and from Medicare from 1999 through 2011. In addition, it examined data for various subgroups of the SHAD veterans studied - for example, enlisted personnel vs. officers, and groups who may have received multiple exposures to one or more of certain substances. The committee also reviewed the scientific literature published since 2000 on the agents, simulants, tracers, and decontaminants used in the tests, from which it generated hypotheses on potential health effects that might be associated with exposure to six of the substances. These hypotheses were used to target portions of the analyses. Exploratory analyses were also performed to ensure that unanticipated associations between SHAD testing and health outcomes in veterans would not be overlooked. Multiple analyses found no evidence of worse health outcomes among SHAD veterans.
The committee acknowledged that its study - like all epidemiological studies - has limitations. Project SHAD occurred more than 50 years ago, making it difficult to account for all of the factors that may have influenced veterans' health. Although a request for classified information on the concentrations of test substances at sampling stations was denied, the committee said it did not expect that the classified information would have altered its findings.
The study by the Institute of Medicine of the National Academies of Sciences, Engineering, and Medicine was sponsored by the U.S. Department of Veterans Affairs. The Academies are private, nonprofit institutions that provide independent, objective analysis and advice to the nation to solve complex problems and inform public policy decisions related to science, technology, and medicine. The Academies operate under an 1863 congressional charter to the National Academy of Sciences, signed by President Lincoln. For more information, visit http://national-academies.org. A committee roster follows.
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Pre-publication copies of Assessing Health Outcomes Among Veterans of Project SHAD (Shipboard Hazard and Defense) are available at http://www.nap.edu. Reporters may obtain a copy from the Office of News and Public Information (contacts listed above)
THE NATIONAL ACADEMIES OF SCIENCES, ENGINEERING, AND MEDICINE
Institute of Medicine
Board on the Health of Select Populations
Committee on Shipboard Hazard and Defense II (SHAD II)
David J. Tollerud, M.D., M.P.H (chair)
Professor and Chair
Department of Environmental and Occupational Health Sciences
School of Public Health and Information Sciences
University of Louisville
Joseph A. Boscarino, Ph.D, M.P.H.
Center for Health Research
Linda A. McCauley, Ph.D., M.N.*
Professor and Dean
Nell Hodgson Woodruff School of Nursing
Thomas E. McKone, Ph.D.
Senior Staff Scientist and Deputy Division Director
Lawrence Berkeley National Laboratory
Kenneth R. Still, Ph.D., M.B.A.
Scientific Director and Senior Toxicology and Industrial Hygiene Consultant
Occupational Toxicology Associates Inc., and
Adjunct Assistant Professor
School of Community Health
College of Urban and Public Affairs
Portland State University
Lake Oswego, Ore.
Beth A. Virnig, M.P.H., Ph.D.
Professor and Senior Associate Dean for Academic Affairs and Research
School of Public Health
University of Minnesota
Yiliang Zhu, Ph.D.
Department of Epidemiology and Biostatistics
College of Public Health, and
Professor, Internal Medicine,
Morsani College of Medicine
University of South Florida
Lois M. Joellenbeck, Dr.P.H.
*Member, National Academy of Medicine