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A comprehensive review of early-onset colorectal SEER data is the first to specifically assess adeno

Embargoed news from Annals of Internal Medicine

Peer-Reviewed Publication

American College of Physicians

Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.

A comprehensive review of early-onset colorectal SEER data is the first to specifically assess adenocarcinomas

Adenocarcinomas are the predominant cancer subtype that is the focus of screening, surveillance and prevention



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In a comprehensive review of SEER (Surveillance, Epidemiology, and End Results) 18 data researchers analyzed histologic colorectal subtypes independently and found that some lesions categorized as colorectal cancer may potentially be lower-risk tumors. The findings are published in Annals of Internal Medicine.

Data indicate that adenocarcinomas are increasing in most early-onset subgroups, but that carcinoids, a distinct type of tumor, are increasing at a faster rate, at least in part because of increased detection and case capture by cancer registries.

Researchers from Tulane University Medical Center reviewed SEER 18 data from 2000 to 2016 for 119,624 patients with colorectal cancer to assess early-onset colorectal cancer incident rates and changes in incident rates over time, stratified by histologic subtype (primarily adenocarcinoma and carcinoid tumors). Adenocarcinoma is key to analyze because it is a target for prevention through screening programs and risk factor stratification (for example, earlier screening for patients with a family history of cancer). The researchers found that 4% to 20% of colorectal cancers were carcinoid tumors as opposed to adenocarcinoma, a proportion that had increased over time. In the rectum, the colonic segment with the largest reported increase in early-onset CRC, up to 34% of lesions depending on patient age, were carcinoid tumors rather than adenocarcinoma in the most contemporary period. This is significant because carcinoid tumors have a distinct pathogenesis from adenocarcinomas.

According to the researchers, these findings are relevant, as they underscore the importance of assessing histologic subtypes independently. If all colorectal cancers are grouped together without stratifying by histologic subtype, it may not be possible to get an accurate account of adenocarcinomas in young patients. Given the focus on early-onset colorectal cancer, it is critical to focus specifically on adenocarcinomas. They also show that although carcinoids are in fact increasing at a faster rate than adenocarcinomas, adenocarcinomas are steadily increasing in almost all early-onset subgroups, including 40-49 year-olds, which has implications for changing average risk screening to age 45. Furthermore, adenocarcinomas still make up the overwhelming majority of colorectal cancers in younger patients.

The researchers note that modeling studies on which the USPSTF screening recommendations are based excluded carcinoid tumors from their analysis, yet the recently released draft guidelines concluded that beginning screening at age 45 provided a better balance of benefit to harm than beginning at age 50. For those in their 20s and 30s, increasing adenocarcinoma rates also underscore the importance of risk stratifying patients by family history and taking symptoms, for example, rectal bleeding, seriously.

The authors of an editorial from The University of Oslo and Oslo University Hospital point out that the medical community, patient organizations, and policymakers have been concerned about a worrisome increase in colorectal cancer in young adults in recent years. For that reason, the American Cancer Society recommended people to start screening at a younger age (45 years instead of 50 years) in 2018. This affects 22 million Americans who now are recommended screening. The authors say this new research is important because it shows that carcinoids contribute to some of the previously reported increase in cancer.

Media contacts: For an embargoed PDF, please contact Lauren Evans at To reach the corresponding author, Jordan J. Karlitz, MD, please contact Keith Brannon at

Also in this issue:

Inpatient Notes: Remdesivir: Making Sense of Emerging Evidence
Megan Rose Curtis, MD, MS; Paul Sax, MD
Annals for Hospitalists

Remote physical exam in heart failure: what is the evidence?
Geno J. Merli, MD; Howard H. Weitz, MD
Consult Guys

The Honors Game
Luisa M. De Souza, MBA, BS
Graphic Medicine


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