Children with high proportions of poly-unsaturated fatty acids (PUFA) in cord blood at birth are more likely to develop respiratory and skin allergies in their early teens, according to research published July 10 in the open access journal PLOS ONE by Malin Barman and colleagues from the Chalmers University of Technology, Sweden.
The researchers followed nearly 800 children born in 1996-97 for diagnosis of allergies at age 13, and studied a subset of 44 who were diagnosed with respiratory allergies, 37 with chronic skin rashes and 48 who did not suffer allergies. Cord blood samples taken at birth from these participants revealed that individuals who suffered allergies later in life had higher proportions of unsaturated fatty acids.
Children with allergies at age 13 had higher proportions of omega-3 and omega-6 PUFAs in cord blood samples taken at birth. Compared to healthy children, allergy sufferers also had lower levels of mono-unsaturated fats in their cord blood. The risk of respiratory allergies in children with higher PUFA levels was equally significant in children with allergic and non-allergic mothers. The study says, "The mechanism by which these lipids affect allergy development is unknown, but may involve dampening of the immune activation in infancy needed for proper maturation of the infant's immune system."
Citation: Barman M, Johansson S, Hesselmar B, Wold AE, Sandberg A-S, et al. (2013) High Levels of Both n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids in Cord Serum Phospholipids Predict Allergy Development. PLOS ONE 8(7): e67920. doi:10.1371/journal.pone.0067920
Financial Disclosure: The work was supported by grants from the Swedish Research Council for Environmental, Agricultural Sciences and Spatial Planning (FORMAS), Stockholm, Sweden, project number 216-2009-752; the Vastra Gotaland Region, Sweden; the Centre for Environment and Sustainability, GMV, Gothenburg, Sweden; the Research and Development Departments of the Jamtland and Norrbotten County Councils, Sweden; and the Th. C. Bergh Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interest Statement: The authors have declared that no competing interests exist.
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