Patients with mild Covid-19 infections experience a significantly increased longer lasting reduced sense of taste and smell. This is also the case for long-term shortness of breath, although relatively few people are affected. And women and the elderly are particularly affected. This is shown by new research findings from Aarhus University Aarhus University Hospital and Regional Hospital West Jutland
The last 14 months have taught us that there are different symptoms and outcomes of Covid-19. However, the vast majority of people who fall ill with Covid-19 experience mild symptoms and get over the disease in two to three weeks.
These are precisely some of the people who have been the subject of a new study from AUH, HEV and AU. In the study, researchers have compared symptoms on a daily basis for up to 90 days in 210 healthcare workers who had tested positive and 630 with a negative test.
Each day, the participants received a link to a questionnaire on whether they had experienced one of the following symptoms within the last 24 hours: coughing, sore throat, headaches, fever, muscle pain, shortness of breath and reduced sense of taste and smell.
"We saw that the prevalence of a longer lasting reduced taste and smell is significantly increased in patients with mild Covid-19 disease who did not require hospitalisation. This pattern is also seen for shortness of breath, but far fewer people were affected," says Henrik Kolstad, who is behind the study.
Women and the elderly experience more symptoms
Thirty per cent of those who had tested positive and almost none of the participants with a negative test reported a reduced sense of taste and smell over the full ninety days. At the beginning of the project, shortness of breath was reported by twenty per cent of those who had tested positive, with the figure falling to five per cent after thirty days, though without ever reaching the level of the participants who had tested negative.
Coughing, sore throat, headaches, muscle pain and fever were more common among those who tested positive than those who tested negative in the first few days, but after thirty days no increases were seen.
Woman with a positive test reported more symptoms compared to women with a negative test than was the case for men with a positive test when compared to men with a negative test. The same was true for older and younger participants. According to the researcher, this could indicate that women and the elderly are more susceptible to developing long-term COVID-19 symptoms.
"This study provides detailed knowledge of which symptom pathways you can expect after having tested positive for COVID-19 without requiring hospitalisation," says Henrik Kolstad.
Background for the results
The study is a cohort study
Partners: The Departments of: Occupational Medicine, Blood Bank and Immunology, Clinical Microbiology, and Infectious Diseases at Aarhus University Hospital; Occupational Medicine, at the Regional Hospitals West Jutland; Business Intelligence, at the Central Denmark Region; The Department of Public Health, Aarhus University; and Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospital.
The study is financed by the Central Denmark Region.
The scientific article can be read in the International Journal of Infectious Diseases: https://pubmed.ncbi.nlm.nih.gov/34022336/
Aarhus University, Department of Clinical Medicine and
Aarhus University Hospital, Occupational Medicine
(+45) 2961 0359
International Journal of Infectious Diseases