image: The absence of recruited neutrophils to the periodontal tissue in LAD patients leads to unrestrained local production of IL-23 and hence IL-17 and G-CSF. Increased IL-17 leads to inflammatory bone loss and dysbiosis, whereas increased G-CSF leads to excessive release of mature neutrophils from the bone marrow. In contrast, normal recruitment of neutrophils regulates the expression of the same cytokines maintaining homeostasis in terms of periodontal health and release of mature neutrophils from the bone marrow. This image relates to a paper that appeared in the Mar. 26, 2014, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. N. Moutsopoulos at the National Institute of Dental and Craniofacial Research, National Institutes of Health in Bethesda, Md., and colleagues was titled, 'Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17 -- Driven Inflammatory Bone Loss.' view more
Credit: Copyright Niki Moutsopoulos and George Hajishengallis (2014)