News Release

LSD and brain connectivity

Peer-Reviewed Publication

Proceedings of the National Academy of Sciences

Based on fMRI data from 25 people, ages 20-34, researchers report changes in effective connectivity between brain regions involved in cortico-striato-thalamo-cortical (CSTC) feedback loops induced by the psychedelic drug LSD, some of which were prevented by treatment with a serotonin 2A receptor antagonist, consistent with the hypothesis that psychedelic drugs affect the brain by disrupting information processing in CSTC loops.

Article #18-15129: "Effective connectivity changes in LSD-induced altered states of consciousness in humans," by Katrin H. Preller et al.

MEDIA CONTACT: Katrin Preller, University Hospital of Psychiatry Zurich, SWITZERLAND; tel: +41-443842625, +41-788977399; e-mail:


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