Below please find a summary and link(s) of new coronavirus-related content published today in Annals of Internal Medicine. The summary below is not intended to substitute for the full article as a source of information. A collection of coronavirus-related content is free to the public at http://go.annals.org/coronavirus.
Multigroup, Adaptively Randomized Trials Are Advantageous for Comparing COVID-19 Interventions
Authors from University of Washington and Fred Hutchinson Cancer Research Center say that broader use of outcome-adaptive randomization when designing clinical trials is especially appropriate to test multiple COVID-19 interventions. This design potentially reduces the number of deaths or other adverse outcomes incurred during a trial. They argue that if interventions are tested separately over the next few months, additional time will be required to conduct direct comparison of the most effective treatments. A collaborative effort will help clinicians to widely implement the most effective treatments as quickly as possible, and with potentially more persons receiving the most effective treatments. Read the full text: https://www.acpjournals.org/doi/10.7326/M20-2933.
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Annals of Internal Medicine