News Release

Deep brain stimulation for refractory severe tinnitus

Preliminary results show safety and efficacy

Peer-Reviewed Publication

Journal of Neurosurgery Publishing Group

Intraoperative DBS

video: Interaction between patient and neurosurgeon during intraoperative caudate stimulation. view more 

Credit: See Cheung SW, Racine CA, Henderson-Sabes J, Demopoulos C, Molinaro AM, Heath S, Nagarajan SS, Bourne AL, Rietcheck JE, Wang SS, and Larson PS: Phase I trial of caudate deep brain stimulation for treatment-resistant tinnitus. Journal of Neurosurgery, published online, ahead of print, September 24, 2019; DOI: 10.3171/2019.4.JNS19347.

Charlottesville, VA (September 24, 2019). Researchers from the University of California San Francisco and Veterans Affairs Health Care System, San Francisco investigated the safety and efficacy of deep brain stimulation in the treatment of refractory severe tinnitus in a small group of patients. They found the procedure to be safe and the results to be encouraging. Detailed findings are found in the article, "Phase I trial of caudate deep brain stimulation for treatment-resistant tinnitus," by Steven W. Cheung, M.D., and colleagues, published today in the Journal of Neurosurgery.


Tinnitus is the perception of sound in the ear with no external stimulus. This sound may take a variety of forms, including ringing, humming, hissing, clicking, pulsating, or roaring. Tinnitus may come and go, or it may be continuous. It is commonly associated with age-related hearing loss, damage to the ear sustained from exposure to loud noises, and an adverse reaction to medications. It can also be impacted by physical or emotional stress, mood changes, and sleep disturbance.

Approximately 15 percent of people experience tinnitus. For most, symptoms are not bothersome and require no treatment. For others whose tinnitus is intrusive, there are a variety of pharmaceutical, acoustic, and behavioral therapies that can help diminish the sound's capacity to cause mental fatigue and degrade sense of well-being. Unfortunately, some people experience tinnitus symptoms that do not respond to available treatments and are so loud and intrusive that they disrupt normal activities of life. For these people a potential new therapy for tinnitus has emerged: deep brain stimulation.

Deep brain stimulation (DBS) surgery is currently performed to treat a variety of movement disorders and some psychological disorders in select patients. During surgery, electrodes attached to the end of leads are implanted deep within the brain in areas where abnormal electrical impulses are disrupted. The leads are connected by insulated wires to an implantable pulse generator, a battery-operated micro-electronic device that is placed elsewhere in the body, just under the skin. The generator delivers electrical stimulation to the brain sites where the leads have been implanted. This stimulation helps relieve patients' rigid limbs and other symptoms.

In earlier studies of DBS as a treatment for movement disorders, researchers found that DBS delivered to the caudate nucleus effected temporary changes in tinnitus loudness in those patients who had tinnitus as a comorbidity. The goals of the present study were threefold: 1) develop a DBS therapy that could reduce the severity of tinnitus in patients in whom other treatments had been ineffective; 2) provide a long-term reduction in the loudness of tinnitus; and 3) provide a critical evaluation of the effects of DBS on tinnitus in patients with no confounding comorbidity such as a movement disorder.

Present Study

The authors report the results of a prospective, open-label, nonrandomized, phase I clinical trial of DBS in five patients (three men and two women, mean age 51 years) with severe tinnitus that had proved refractory to acoustic or behavioral treatments. Four of the patients reported tinnitus in both ears and one patient reported it in only one ear. Their tinnitus produced such a negative impact on their lives that they chose to undergo an unproved invasive procedure in the hopes that it could provide meaningful relief of their symptoms.

Each patient underwent stereotactic neurosurgery to implant DBS electrodes in the caudate nucleus on each side of the brain. The patients were awake during surgery and interacted with the surgical team, which helped the team determine the final position of the leads. There were no serious surgery-related adverse events in these patients.

After a five-week period of postoperative healing, the patients began a stimulation optimization period during which settings on the DBS internal pulse generator were periodically adjusted in the clinic and at home by the patient. The goal was to find a stimulation setting that would prove optimal for reducing the severity of tinnitus for each patient, and thus this period varied in length (5 to 13 months) according to each patient's needs.

Once a promising stimulation setting had been determined, the patients entered a 24-week-long period of constant stimulation at that setting. Minor setting adjustments were made in only one patient during that time period.

Overall, DBS proved effective in diminishing the negative experience of tinnitus, although each patient experienced the effect differently. Various tests were applied to measure the efficacy of DBS in tinnitus. A comparison of the patients' Tinnitus Functional Index scores before treatment and during constant stimulation showed significant clinical improvement in three patients (60%). A comparison of the patients' Tinnitus Handicap Inventory scores before treatment and during constant stimulation showed significant clinical improvement in four patients (80%). One patient found no relief.

In this group of five patients, there were no serious surgery- or stimulation-related adverse effects. Surgery-related adverse events included postoperative incisional pain and headache, which were expected and resolved quickly. Stimulation-related adverse events included worsening of tinnitus symptoms and, in one patient, visual phantoms that occurred briefly while the stimulation settings were being adjusted.

Given the promising outcomes of this study, the authors look forward to a phase II study. They suggest that this next trial could benefit by a refinement of the target position of the DBS leads, with the aim of shortening the stimulation optimization period and making the treatment effect more uniform.

When asked about the study, Dr. Cheung said, "Our research team from the disciplines of Neurosurgery, Neurology, Otolaryngology, and Radiology worked synergistically to tackle the challenging condition of treatment-resistant tinnitus. We are encouraged by results of this phase I trial and hope to use a personalized targeting approach to implant electrodes in a phase II trial to improve efficacy."


Links in the paper bring the reader to two online videos. The first, taken during surgery, shows interaction between the neurosurgeon and a patient while testing caudate stimulation. The second shows a brief interview with the patient after 24 weeks of continuous stimulation.

The paper is accompanied by an editorial, "Deep brain stimulation for tinnitus: exploring the frontier between sensory perception and awareness," by Martin Jakobs and Andres M. Lozano (

Cheung SW, Racine CA, Henderson-Sabes J, Demopoulos C, Molinaro AM, Heath S, Nagarajan SS, Bourne AL, Rietcheck JE, Wang SS, and Larson PS: Phase I trial of caudate deep brain stimulation for treatment-resistant tinnitus. Journal of Neurosurgery, published online, ahead of print, September 24, 2019; DOI: 10.3171/2019.4.JNS19347.

Acknowledgments: This study was supported by the NIH-NIDCD (grant no. 5 U01DC013029 to S.W.C.); Department of Defense (grant nos. W81XWH-13-1-0494 and W81XWH1810741 to S.W.C.); and Coleman Memorial Fund (S.W.C.). It was performed under an IDE issued by the FDA (IDE no. G120132 to P.S.L.).

Clinical Trial registration no.: NCT01988688 (

Disclosure: Dr. Larson has received honoraria from and Ms. Heath has been an educator and consultant for DBS courses and course development for Medtronic, the company that manufactures the DBS device used for this study.

For additional information, please contact: Ms. Jo Ann M. Eliason, Communications Manager, Journal of Neurosurgery Publishing Group, One Morton Drive, Suite 200, Charlottesville, VA 22903. Email:; Phone: 434-982-1209.

For 75 years, the Journal of Neurosurgery has been recognized by neurosurgeons and other medical specialists the world over for its authoritative clinical articles, cutting-edge laboratory research papers, renowned case reports, expert technical notes, and more. Each article is rigorously peer reviewed. The Journal of Neurosurgery is published monthly by the JNS Publishing Group, the scholarly journal division of the American Association of Neurological Surgeons. Other peer-reviewed journals published by the JNS Publishing Group include Neurosurgical Focus, Neurosurgical Focus: Video, the Journal of Neurosurgery: Spine, and the Journal of Neurosurgery: Pediatrics. All five journals can be accessed at

Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with more than 10,000 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. All active members of the AANS are certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons (Neurosurgery) of Canada or the Mexican Council of Neurological Surgery, AC. Neurological surgery is the medical specialty concerned with the prevention, diagnosis, treatment, and rehabilitation of disorders that affect the entire nervous system including the brain, spinal column, spinal cord, and peripheral nerves. For more information, visit

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