image: This is an H&E-stained section of lungs in C57Bl/6 neonatal mice exposed in utero to filtered air and challenged with PBS (control) show minimal to no inflammation, as expected. view more
Credit: Carmen Lau
科研人员报告说,与在子宫内暴露于经过过滤的空气的小鼠相比,在子宫内暴露于超精细颗粒物(UFP)的小鼠没能对室内尘螨过敏原发展出强的免疫应答,并且在4周龄的时候,肺泡炎症更少,在它们的肺泡灌洗液中有更少的白细胞;一种对于氧化压力敏感的小鼠品种的这种免疫抑制更加明显,这表明了对超精细颗粒物(UFP)做出响应的母亲氧化压力可能改变胎儿免疫发育,而在子宫内超精细颗粒物(UFP)暴露可能让新生儿易于遭到呼吸系统感染。
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Journal
Proceedings of the National Academy of Sciences