Obesity and its duration are significant risk factors for type 2 diabetes, cardiovascular events, multiple cancers and decreased quality of life. According to the Centers for Disease Control and Prevention, obesity affects 20.6% of adolescents ages 12-19 in the United States, meaning a potential lifetime of dealing with this condition. Complications from obesity can also result in a potentially decreased life expectancy of five to 20 years for these youth. In a new study published in Pediatrics, researchers at Children's Hospital Colorado (Children's Colorado) have found that both younger and older adolescents have similar weight loss, resolution of high blood pressure and high cholesterol, nutritional impacts and improvement in quality of life after bariatric surgery. These results strongly indicate that, when working with adolescents with severe obesity, age alone should not dissuade providers and patients from pursuing surgery when medically indicated.
"Bariatric surgery has become recognized as the safest and most effective treatment for severe obesity in adults; however, little was known about the relative merits and risks of these procedures in the youngest of teens compared to older adolescents," said Sarah B. Ogle, DO, a surgery fellow at Children's Colorado. "Thus, discussing the option of surgery in young adolescents with intractable severe obesity makes more sense than continuing ineffective treatments, given the proven benefits of surgery. This study is an exciting step toward demonstrating the safety and efficacy of bariatric surgery in the youngest adolescents."
Specifically, the study compared outcomes data of 228 adolescents enrolled in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS). Each of these patients underwent bariatric surgery. Sixty-six of them were between the ages of 13 and 15 at the time of surgery while 162 of them were between the ages of 16 and 19.
Baseline data were collected within 30 days of surgery. Participants were then evaluated at six months, 12 months, and then annually, for five years after surgery. Researchers compared weight loss, comorbidity resolution, nutritional abnormalities and quality of life between the younger and older adolescents participating in the study.
No significant differences in the remission of high blood pressure or high cholesterol were observed between the age groups. Weight loss and quality of life were similar in the two groups. Further, younger adolescents were less likely to develop elevated transferrin, which plays a central role in iron metabolism, and low vitamin D.
"Younger teens have less commonly been considered eligible for surgery due to their age, but the findings in this analysis should shift the focus from a concern about age to more important factors that should drive decision-making. These include providing the patient with the best opportunity to reach a normal BMI after surgery, reversal of serious complications of obesity, and treatment that will most likely increase the lifespan," said Thomas H. Inge, MD, PhD, Teen-LABS principal investigator, and director of pediatric surgery and the bariatric center at Children's Colorado. "While these results are promising, longer term study of this early intervention is needed to fully evaluate the impact of surgery to reverse late effects of childhood severe obesity that develop over the decades."
Teen-LABS was established in 2007 and is the largest and only multicenter, National Institutes of Health (NIH)-sponsored research on adolescent bariatric surgery. This ongoing study involves six clinical centers around the U.S., including Children's Hospital Colorado, Cincinnati Children's Hospital Medical Center, Nationwide Children's Hospital, Texas Children's Hospital, Children's Hospital of Alabama and the University of Pittsburgh Medical Center.
The Teen-LABS consortium is funded by cooperative agreements with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through grants: UM1DK072493 (PI, Dr. Thomas Inge, University of Colorado, Denver) and UM1DK095710 (PI, Dr. Changchun Xie, University of Cincinnati).
ABOUT CHILDREN'S HOSPITAL COLORADO
Children's Hospital Colorado is one of the nation's leading and most expansive pediatric healthcare systems with a mission to improve the health of children through patient care, education, research and advocacy. Founded in 1908 and recognized as a top 10 children's hospital by U.S. News & World Report, Children's Colorado has established itself as a pioneer in the discovery of innovative and groundbreaking treatments that are shaping the future of pediatric healthcare worldwide. Children's Colorado offers a full spectrum of family-centered care at its urgent, emergency and specialty care locations throughout Colorado, including its location on the Anschutz Medical Campus, and across the region. In 2019, Children's Hospital Colorado, Colorado Springs, opened as the first pediatric-only hospital in southern Colorado. For more information, visit http://www.childrenscolorado.org, or connect with us on Facebook and Twitter.
Children's Hospital Colorado complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex.
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