Researchers at the Yerkes National Primate Research Center, Emory University, have demonstrated that prairie voles may be a useful model in understanding the neurochemistry of social behavior. By influencing early social experience in prairie voles, researchers hope to gain greater insight into what aspects of early social experience drive diversity in adult social behavior. The study is currently available online in a special edition of Frontiers in Behavioral Neuroscience that is focused on the long-term impact of early life experiences.
Prairie voles are small, highly social, hamster-sized rodents that often form stable, life-long bonds between mates. In the wild, there is striking diversity in how offspring are reared. Some pups are reared by single mothers, some by both parents (with the father providing much of the same care as the mother), and some in communal family groups.
Researchers Todd Ahern, a graduate student in the Emory University Neuroscience Program, and Larry Young, PhD, professor of psychiatry and behavioral sciences at the Yerkes Research Center and Emory University School of Medicine, compared pups raised by single mothers (SM) to pups raised by both parents (BP) to determine the effects of these types of early social environments on adult social behavior.
"Our findings demonstrate that SM- and BP-reared animals experienced different levels of care during the neonatal period and that these differences significantly influenced bonding social behaviors in adulthood," says Ahern.
"These results suggest naturalistic variation in social rearing conditions can introduce diversity into adult nurturing and attachment behaviors. SM-raised pups were slower to make life-long partnerships, and they showed less interest in nurturing pups in their communal families," says Young.
Researchers also found differences in the oxytocin system. Oxytocin is best known for its roles in maternal labor and suckling, but, more recently, it has been tied to prosocial behavior, such as bonding, trust and social awareness.
"Very simply, altering their early social experience influenced adult bonding," says Ahern. Further studies will look at the altered oxytocin levels in the brain to determine how these hormonal changes affect relationships.
Funding for the research came from the National Institutes of Health, the Yerkes National Primate Research Center, base grant 5 P51 RR000165, and the Center for Behavioral Neuroscience.
For nearly eight decades, the Yerkes National Primate Research Center, Emory University, has been dedicated to conducting essential basic science and translational research to advance scientific understanding and to improve the health and well-being of humans and nonhuman primates. Today, the center, as one of only eight National-Institutes of Health-funded national primate research centers, provides leadership, training and resources to foster scientific creativity, collaboration and discoveries. Yerkes-based research is grounded in scientific integrity, expert knowledge, respect for colleagues, and open exchange of ideas and compassionate quality animal care.
Within the fields of microbiology, immunology, neuroscience and psychobiology, the center's research programs are seeking ways to: develop vaccines for infectious and noninfectious diseases, such as AIDS and Alzheimer's disease; treat cocaine addiction; interpret brain activity through imaging; increase understanding of progressive illnesses such as Parkinson's and Alzheimer's; unlock the secrets of memory; determine behavioral effects of hormone replacement therapy; address vision disorders; and advance knowledge about the evolutionary links between biology and behavior.
The Robert W. Woodruff Health Sciences Center of Emory University is an academic health science and service center focused on missions of teaching, research, health care and public service. Its components include the Emory University School of Medicine, Nell Hodgson Woodruff School of Nursing, and Rollins School of Public Health; Yerkes National Primate Research Center; Emory Winship Cancer Institute; and Emory Healthcare, the largest, most comprehensive health system in Georgia. Emory Healthcare includes: The Emory Clinic, Emory-Children's Center, Emory University Hospital, Emory University Hospital Midtown, Wesley Woods Center, Emory University Orthopaedics & Spine Hospital, the jointly owned Emory-Adventist Hospital, and EHCA, a limited liability company created with Hospital Corporation of America. EHCA includes two joint venture hospitals, Emory Eastside Medical Center and Emory Johns Creek Hospital. The Woodruff Health Sciences Center has a $2.3 billion budget, 18,000 employees, 2,500 full-time and 1,500 affiliated faculty, 4,300 students and trainees, and a $5.5 billion economic impact on metro Atlanta.
Frontiers in Behavioral Neuroscience