News Release

New DoD funded study to tackle chronic amputee pain for veterans and civilians

Northwestern Medicine researchers begin clinical trial to review new treatment for chronic amputee pain

Business Announcement

Northwestern Memorial HealthCare

CHICAGO - Northwestern Medicine® researchers are leading a new multi-center clinical trial to evaluate a unique surgical method, known as targeted muscle reinnervation (TMR), to treat chronic pain that can result from limb amputation. Around a quarter of all amputees develop chronic pain in the remaining portion of their amputated limb, which can include phantom limb syndrome (pain that is perceived in the portion of the limb that is gone), and prevents many patients from using prostheses. While there are many causes for amputation, more than 1,000 active military personnel have had a major limb amputation due to combat-related injuries in recent conflicts.

Northwestern Memorial Hospital is the lead site for the four-year study, "Targeted Reinnervation as a Means to Treat Neuromas in Major Limb Amputation," which is funded by the Department of Defense's (DoD) Office of Congressionally Directed Medical Research. Other participating sites include Walter Reed National Military Medical Center, The University of Washington Medical Center and Harborview Medical Center, and San Antonio Military Medical Center as participating sites.

"The problem for amputees that experience chronic pain isn't that the limb itself was removed," said Northwestern Medicine's chief of plastic surgery and principal investigator for the study, Gregory A. Dumanian, MD. "The problem is that the nerves that used to control the amputated limb are incomplete, but also remain active, constantly sending signals to the brain. These separated nerves cannot heal properly without the chance to connect to other nerve tissue, and end up creating painful growths called neuromas."

The current standard of care for a painful amputee neuroma is to remove the nerve growth and then place the nerve ending into a nearby muscle for extra cushioning. While this treatment can reduce neuroma pain, it is not always successful and still leaves the nerve active and disconnected to inevitably create a new neuroma.

The TMR therapy's goal is to transfer a nerve that has been cut-off from the muscles it used to control and essentially plug it into a functioning muscle nearby. This is accomplished by removing the neuroma from the damaged nerve, and then surgically joining it with a healthy nerve that controls the existing target muscle. Joining these nerves together allows them to then grow into, or reinnervate, the target muscle and prevent the neuroma from reforming.

"TMR is a completely new approach to treating neuroma induced pain for amputees," said co-investigator Todd Kuiken, MD, PhD, a Northwestern Medicine physiatrist who is director of the Center for Bionic Medicine at the Rehabilitation Institute of Chicago (RIC) and professor of surgery at the Northwestern University Feinberg School of Medicine. "Instead of trying to treat a painful neuroma by burying it, this procedure provides damaged nerves with a new purpose. After TMR, patients can use these previously unable nerves to contract their target muscle and their repurposed signals can even be detected and used to control prostheses."

TMR was pioneered in 2002 by Dumanian at Northwestern Memorial in conjunction with Kuiken in order to address the rehabilitation needs of amputees. Since 2002, TMR has now been performed successfully more than 100 times worldwide and nearly all of the patients who had painful neuromas before the procedure reported no neuroma pain afterward.

"By giving an amputee's damaged nerves a new purpose, we have seen TMR improve many lives," added Dumanian, who is also a professor at the Feinberg School of Medicine. "Now we have the chance to test TMR in a large clinical trial which will allow us to take the next steps toward the possibility of making it a new standard of care."

The clinical trial will use an online pain questionnaire and MRI imaging of the nerves treated before and after surgery to compare the outcomes of TMR and the current standard surgical treatment for painful neuromas. The research is supported by the DoD's Office of Congressionally Directed Medical Research grant OR120021 and will seek to enroll a total of 200 individuals across all four centers, making it the largest neuroma study ever performed.


To learn more about the "Targeted Reinnervation as a Means to Treat Neuromas in Major Limb Amputation" clinical trial, visit or call 312-695-5142.

About Northwestern Medicine®

Northwestern Medicine® is the collaboration between Northwestern Memorial HealthCare and Northwestern University Feinberg School of Medicine around a strategic vision to transform the future of healthcare. It encompasses the research, teaching and patient care activities of the academic medical center. Sharing a commitment to superior quality, academic excellence and patient safety, the organizations within Northwestern Medicine comprise more than 9,000 clinical and administrative staff, 3,100 medical and science faculty and 700 students. The entities involved in Northwestern Medicine remain separate organizations. Northwestern Medicine is a trademark of Northwestern Memorial HealthCare and is used by Northwestern University.

About Northwestern Memorial Hospital

Northwestern Memorial is one of the country's premier academic medical center hospitals and is the primary teaching hospital of the Northwestern University Feinberg School of Medicine. Along with its Prentice Women's Hospital and Stone Institute of Psychiatry, the hospital has 1,705 affiliated physicians and 6,769 employees. Northwestern Memorial is recognized for providing exemplary patient care and state-of-the art advancements in the areas of cardiovascular care; women's health; oncology; neurology and neurosurgery; solid organ and soft tissue transplants and orthopaedics.

Northwestern Memorial has nursing Magnet Status, the nation's highest recognition for patient care and nursing excellence. Northwestern Memorial ranks 10th in the nation in the U.S. News & World Report 2014-15 Honor Roll of America's Best Hospitals. The hospital is recognized in 14 of 16 clinical specialties rated by U.S. News and is No. 1 in Illinois and Chicago in U.S. News' 2014-15 state and metro rankings, respectively. For 14 years running, Northwestern Memorial has been rated among the "100 Best Companies for Working Mothers" guide by Working Mother magazine. The hospital is a recipient of the prestigious National Quality Health Care Award and has been chosen by Chicagoans as the Consumer Choice according to the National Research Corporation's annual survey for 15 consecutive years.

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