Alexandria, Va., USA - The International Association for Dental Research (IADR) and the American Association for Dental Research (AADR) announced the 2021 IADR/AADR Journal of Dental Research Cover of the Year, 2020 for the paper "Single-Cell RNA-seq Identifies Cell Diversity in Embryonic Salivary Glands" (J Dent Res 99(1): 69-78). The authors were recognized during the Opening Ceremonies of the virtual 99th General Session & Exhibition of the IADR, held in conjunction with the 50th Annual Meeting of the AADR and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021.
The authors of this article are Rei Sekiguchi, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Md., USA, Dani Martin Izquierdo, Genomics and Computational Biology Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Md., USA, and Kenneth M. Yamada, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Md., USA.
In this study, the researchers performed single-cell transcriptome analyses of 14,441 cells from embryonic day 12 submandibular and parotid salivary glands to characterize their molecular identities during bud initiation. The findings demonstrate that the establishment of transcriptional identities emerges early in development, primarily in the mesenchyme of developing salivary glands. The authors presented the first comprehensive description of molecular signatures that define specific cellular landmarks for the bud initiation stage, when the neural crest-derived ectomesenchyme predominates in the salivary mesenchyme that immediately surrounds the budding epithelium. The authors also provided the first transcriptome data for the largely understudied embryonic parotid gland as compared with the submandibular gland, focusing on the mesenchymal cell populations.
The JDR Cover of the Year Award, 2020 image shows an embryonic murine submandibular gland (day 16), with neuronal tissues (cyan) extending prominent projections adjacent to branching salivary epithelium (magenta). Developing acini are surrounded by emerging myoepithelial cells (green and yellow). Stark differences were found between the gene expression patterns of submandibular and parotid glands early in development for both neuronal and myoepithelial/muscle-related populations.
The award, voted on by the IADR/AADR Publications Committee, honors the cover that features an aesthetically pleasing, scientifically novel image that enhances the impact of the article. All 13 JDR covers from 2020 were reviewed.
View a PDF of this press release.
About the Journal of Dental Research
The IADR/AADR Journal of Dental Research (JDR) is a multidisciplinary journal dedicated to the dissemination of new knowledge in all sciences relevant to dentistry and the oral cavity and associated structures in health and disease. The JDR 2-year Journal Impact Factor™ is 6.116, ranking #5 of 91 journals in the "Dentistry, Oral Surgery & Medicine" category, and the JDR 5-year Journal Impact Factor™ is 7.199. The JDR ranks #1 of 91 journals in total citations at 26,197 and Eigenfactor at 0.01683. The JDR Editor-in-Chief is Nicholas Jakubovics, Newcastle University, England. Follow the JDR on Twitter at @JDentRes!
International Association for Dental Research
The International Association for Dental Research (IADR) is a nonprofit organization with over 10,000 individual members worldwide, with a mission to drive dental, oral and craniofacial research for health and well-being worldwide. To learn more, visit http://www.iadr.org. The American Association for Dental Research (AADR) is the largest Division of IADR with 3,100 members in the United States. To learn more, visit http://www.iadr.org/aadr.