image: Nanoparticles intercept innate immune cells in circulation to alter their relative trafficking between the spleen and the spinal cord. Additionally, the nanoparticles alter the phenotype of the cells, which leads to a microenvironment in the spinal cord that is anti-inflammatory and permissive to regeneration. view more
Credit: Image courtesy of Liam Casey (University of Michigan, Ann Arbor, MI).
使用一个脊髓损伤的小鼠模型的科研人员报告说，静脉注射不含活性药物成分的纳米颗粒，拦截了血液中的免疫细胞并且把这些细胞的特性重编程为它们到达脊髓之前，而免疫细胞在受损部位的数量减少，减少了受损部位的破坏性的炎症以及瘢痕；这组作者说，这些结果还提示，纳米颗粒给药促进了一个再生恢复环境，促进了功能恢复。
###
Journal
Proceedings of the National Academy of Sciences