PITTSBURGH, Jan. 21, 2020 - Overweight and obese vitamin D-deficient children who took a relatively high dose of vitamin D every day for six months had lower blood pressure and improved insulin sensitivity than their peers who took a lower dose, according to the results of a UPMC Children's Hospital of Pittsburgh clinical trial reported in The American Journal of Clinical Nutrition.
However, the study did not show improvements in other markers of cardiovascular and metabolic health, a finding that indicates vitamin D supplementation alone may not be the cure-all for improving the heart health of children at highest risk for diabetes and heart disease.
"Current recommendations for taking vitamin D are pegged to optimal bone health," said lead author Kumaravel Rajakumar, M.D., M.S., professor of pediatrics at the University of Pittsburgh School of Medicine. "But we know vitamin D is involved in more than building healthy bones. It can turn on and off genes that direct our cells to regulate blood glucose levels, and immune and vascular function."
Rajakumar and his colleagues enrolled 225 healthy, but vitamin D-deficient, 10- to 18-year-old children in Pittsburgh who were overweight or obese in the clinical trial, and 211 of them were black. People with darker skin have higher amounts of melanin pigment in their skin and are more likely than their lighter-skinned counterparts to be vitamin D deficient. This is because vitamin D is made in the body when the skin is directly exposed to sunlight, and melanin in the skin acts as a natural sunscreen and inhibits vitamin D production. Overweight and obese children also have a higher risk of vitamin D deficiency, as well as developing diabetes and heart disease.
The children were split into three groups and given pills that appeared identical, but contained different quantities of vitamin D, which is measured in international units, or IUs. One group received a 600 IU tablet daily, which is the current recommended daily dietary allowance. The other two groups received either a 1,000 IU or 2,000 IU tablet daily, still well below the 4,000 IU daily maximum considered safe for children in this age range. During the trial, neither the participants, nor their doctors, knew which dose each child was receiving.
Blood tests showed that the higher the daily dose of vitamin D, the greater the improvement in the participants' blood concentration of vitamin D. By the conclusion of the trial, none of the groups was considered vitamin D deficient.
After six months, the children receiving the daily 2,000 IU vitamin D supplement had a reduced fasting blood glucose level and improved insulin sensitivity -- both of which reduce susceptibility to diabetes and improve cardiovascular health. After six months, the children receiving 1,000 IUs of vitamin D daily had lower blood pressure. High blood pressure is bad because it increases risk of heart attack, stroke and kidney disease.
The study did not reveal any significant changes in measures of the health of the membrane that lines the blood vessels or arterial stiffness -- both of which are strong indicators of heart health and were the primary measures that the researchers were seeking to influence with vitamin D supplementation.
"There are many reasons we might not have seen changes in endothelial function or arterial stiffness," said Rajakumar, who also is a pediatrician at UPMC Children's Hospital. "Maybe vitamin D simply doesn't influence these, or perhaps we didn't reach and maintain a level of vitamin D to cause an effect. It could also be that our trial didn't run long enough. However, treatment of vitamin D deficiency with these higher daily doses can have a positive impact on cardiometabolic health of children, without negative side effects."
The senior author on this study is Steven E. Reis, M.D., of Pitt. Additional authors are Charity G. Moore, Ph.D., Arshad T. Khalid, M.S., Abbe N. Vallejo, Ph.D., Mohamed A. Virji, M.D., Ph.D., Susan L. Greenspan, M.D., and Silva Arslanian, M.D., all of Pitt, UPMC Children's, or both; and Michael F. Holick, Ph.D., M.D., of Boston University Medical Center.
This research was supported by National Institutes of Health grants R01HL112985, UL1 TR001857 and P30 AG024827, a UPMC Children's Hospital of Pittsburgh Research Advisory Committee seed grant, and an IRG Award from the Nancy E. Taylor Foundation for Chronic Diseases.
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About the University of Pittsburgh School of Medicine
As one of the nation's leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1998. In rankings recently released by the National Science Foundation, Pitt ranked fifth among all American universities in total federal science and engineering research and development support.
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About UPMC Children's Hospital of Pittsburgh
Regionally, nationally, and globally, UPMC Children's Hospital of Pittsburgh is a leader in the treatment of childhood conditions and diseases, a pioneer in the development of new and improved therapies, and a top educator of the next generation of pediatricians and pediatric subspecialists. With generous community support, UPMC Children's Hospital has fulfilled this mission since its founding in 1890. UPMC Children's is recognized consistently for its clinical, research, educational, and advocacy-related accomplishments, including ranking in the top 10 on the 2019-2020 U.S. News & World Report Honor Roll of America's Best Children's Hospitals. UPMC Children's also ranks 15th among children's hospitals and schools of medicine in funding for pediatric research provided by the National Institutes of Health (FY2018).
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American Journal of Clinical Nutrition