image: SNHG12 knockdown (KD) triggers DNA damage and senescence in the vessel wall leading to accelerated atherosclerosis (Oil red O (red staining) for lipid content) and plaque necrosis (circled). This material relates to a paper that appeared in the Feb. 19, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by S. Haemmig at Brigham and Women's Hospital in Boston, MA; and colleagues was titled, "Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence." view more
Credit: [Credit: Stefan Haemmig/Mark W. Feinberg]