A 20-year-old HIV-positive adult on antiretroviral therapy (ART) in the U.S. or Canada may be expected to live into their early 70's, a life expectancy approaching that of the general population, according to results published December 18, 2013, in the open access journal PLOS ONE by Hasina Samji and colleagues from the British Columbia Centre for Excellence in HIV/AIDS (BC-CfE) and the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD).
The life expectancies of nearly 23,000 individuals on ART were calculated based on mortality rates in the early to mid-2000s. Participants in the study were from the NA-ACCORD and aged 20 years or older. Changes in life expectancy from 2000 to 2007 among HIV-positive individuals were then evaluated by selected sociodemographic and clinical characteristics, such as drug use history and immune cell counts
The authors found that life expectancy at age 20 increased from 36.1 to 51.4 years from 2000-2002 to 2006-2007. Men and women had comparable life expectancies in all periods except the last (2006-2007). Life expectancy was lower for individuals with a history of injection drug use, those who were non-white, and those who initiated ART with low CD4 count (a count of cells that activate the immune response) compared to those who started at a higher count. The results of this study indicate increasing longevity for individuals living with HIV in the U.S. and Canada and contribute to the growing evidence that HIV-positive people on ART have life expectancies approaching those in general populations.
Citation: Samji H, Cescon A, Hogg RS, Modur SP, Althoff KN, et al. (2013) Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada. PLoS ONE 8(12): e81355. doi:10.1371/journal.pone.0081355
Financial Disclosure: This work was supported by grants U01-AI069918, U10-AA13566, U01-AI31834, U01-AI34989, U01-AI34993, U01-AI34994, U01-AI35004, U01-AI35039, U01-AI35040, U01-AI35041, U01-AI35042, U01-AI35043, U01-AI37613, U01-AI37984, U01-AI38855, U01-AI38858, U01-AI42590, U01-AI68634, U01-AI68636, U01-HD32632, U10-EY08057, U10-EY08052, U10-EY08067, UL1-RR024131, UL1-RR024131, M01-RR-00052, M01-RR00071, M01-RR00079, M01-RR00083, M01-RR00722, M01-RR025747, P30-AI27757, P30-AI27767, P30-AI27763, P30-AI50410, P30-AI54999, R01-DA04334, R01-DA12568, R01-DA11602, R01-AA16893, R24-AI067039, Z01-CP010176, AHQ290-01-0012, N02-CP55504, AI-69432, AI-69434, K01-AI071725, K23-AI610320, K23-EY013707, K24-DA00432, K24 AI65298 and K01-AI093197 from the National Institutes of Health; contract 290-01-0012 from the Agency for Healthcare Research and Quality; contract CDC200-2006-18797 from the CDC; grants TGF-96118, HCP-97105, CBR-86906, CBR-94036, KRS-86251, and 169621 from the Canadian Institutes of Health Research; the Canadian HIV Trials Network, project 24; and the government of British Columbia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interest Statement: The authors have declared that no competing interests exist.
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