News Release

Aortic valve replacement appears safe, effective in very elderly patients

New study published in The Annals of Thoracic Surgery

Peer-Reviewed Publication


Chicago, October 29, 2014 – Aortic valve replacement (AVR) can safely be used to treat severe aortic stenosis in patients age 90 years and older and is associated with a low risk of operative stroke and mortality, according to a study in the November 2014 issue of The Annals of Thoracic Surgery.

Key points

  • Aortic valve replacement appears to be safe and effective for patients over age 90 years with severe aortic stenosis.

  • Four out of five (81.3%) patients were alive 1 year following AVR.

  • TAVR had similar rates of morbidity and mortality as traditional surgical AVR.

The elderly population in the US is steadily growing. From 2000 to 2010 alone, the Department of Health & Human Services Administration on Aging reports an increase of 1.3 million elderly people.

Takashi Murashita, MD, Kevin L. Greason, MD, and colleagues from Mayo Clinic in Rochester, Minn., reviewed the records of 59 patients who were at least 90 years of age (nonagenarians) and who underwent aortic valve replacement for severe aortic stenosis (narrowing of the aortic valve which obstructs blood flow from the heart).

"An increasing number of nonagenarian patients are willing to undergo AVR to improve both the quality and quantity of their life," said Dr. Murashita.

Among the patients in the study, surgical AVR (SAVR) was used in 33 (56%) and transcatheter AVR (TAVR; minimally invasive treatment for patients who can't undergo open heart surgery) was used in 26 (44%). Three patients died following AVR, including two patients who received SAVR and one who received TAVR. Survival at 1-year post-surgery was 81.3% with no significant difference between the two groups. Twenty-two patients (37.3%) had operative complications, which included acute renal failure and stroke.

Among patients in the SAVR group, five (21.7%) were discharged home compared with 12 patients (48%) in the TAVR group. The remaining 31 patients were all discharged to a skilled nursing home facility.

"We hope that, through our results, providers will understand that aortic valve replacement should not be denied in select symptomatic nonagenarian patients with severe aortic valve stenosis," said Dr. Greason. "Nearly 80% of our patients had significant heart failure symptoms prior to surgery and most experienced marked improvement following the operation."

Dr. Murashita added that, as TAVR becomes more widely available, an increasing number of nonagenarian patients may opt for the less invasive procedure.


Notes for editors

"Aortic Valve Replacement for Severe Aortic Valve Stenosis in the Nonagenarian Patient" (10.1016/j.athoracsur.2014.06.015)The Annals of Thoracic Surgery published by Elsevier.

Full text of the article is available to credentialed journalists upon request; contact Cassie McNulty at +1 312 202 5865

About The Annals of Thoracic Surgery

The Annals of Thoracic Surgery is the official journal of the Society of Thoracic Surgeons (STS) and the Southern Thoracic Surgical Association. Founded in 1964, The Society of Thoracic Surgeons is a not-for-profit organization representing more than 6,800 cardiothoracic surgeons, researchers, and allied health care professionals worldwide who are dedicated to ensuring the best possible outcomes for surgeries of the heart, lung, and esophagus, as well as other surgical procedures within the chest. The Society's mission is to enhance the ability of cardiothoracic surgeons to provide the highest quality patient care through education, research, and advocacy.

About Elsevier

Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions — among them ScienceDirect, Scopus, Elsevier Research Intelligence and ClinicalKey — and publishes nearly 2,200 journals, including The Lancet and Cell, and over 25,000 book titles, including a number of iconic reference works.

The company is part of Reed Elsevier Group PLC, a world-leading provider of professional information solutions in the Science, Medical, Legal and Risk and Business sectors, which is jointly owned by Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).

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