image: Chemical structures of macrocycle backbones illustrating the large structural diversity of the newly generated macrocyclic compound libraries. This material relates to a paper that appeared in the August 21st, 2019, issue of Science Advances, published by AAAS. The paper, by S.S. Kale at Ecole Polytechnique Fédérale de Lausanne (EPFL) in Lausanne, Switzerland, and colleagues was titled, "Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kDa ligands." view more
Credit: Dr. Sangram Kale (Heinis lab, EPFL)