News Release

Scientists map the brain of a nematode worm

Peer-Reviewed Publication

University of Leeds

Map of the brain of the nematode worm C elegans

image: The spatial organisation of the C. elegans brain is modular. The image shows the different brain regions that process information to direct behaviours such as navigation, avoidance and feeding. The sensors collect information from the nose (top left, not shown) and drive muscles all around the head and down the body (to the bottom right, not shown) view more 

Credit: University of Leeds

Researchers have mapped the physical organization of the brain of a microscopic soil-living nematode worm called Caenorhabditis elegans, creating a new model for the architecture of the animal's brain and how it processes information.

In a surprise twist, they found a large degree of variation in the structure of some neural circuits or pathways in individual worms which complemented a core set of neural circuits common to different animals.

The scientists say the worms' brains might have a lot more in common with larger animals than previously thought.

Created by neuroscientists at the University of Leeds in collaboration with researchers in New York's Albert Einstein College of Medicine, the brain map reveals that different spatial regions support different specialised circuits for routing information in the brain, where information is integrated before being acted upon.

The study - A multiscale brain map derived from whole-brain volumetric reconstructions - is published today (24 Feb) in the scientific journal Nature. (The paper will be available on this link when the embargo lifts:

C. elegans are nematodes that feed on bacteria found in rotting vegetation in your garden. They are only around a millimetre in length and as thin as a human hair.

An adult worm has exactly 302 cells in its nervous system - by comparison, the human brain has around 100 billion cells. But almost two thirds of the worm's nerve cells form a ring in the head region, where they make thousands of connections with each other.

This 'brain' is the control centre of the animal, where much of the sensing and decision-making takes place.

Even though the brain is very compact, the animal displays a range of complex behaviours, and neuroscientists have been interested in understanding its brain for decades. Previous studies have created 'wiring diagrams' for the connections between nerve cells.

This latest study, though, is the first to provide the complete spatial coordinates to those circuit diagrams.

Professor Netta Cohen, Computational Neuroscientist at the University of Leeds, who supervised the research, said: "The brain needs to organise information flow to control the animal's behaviour. But how the structure and function of the brain are related is an open question. Providing the spatial representation of the circuitry has allowed us to uncover the modular structure of this animal's brain."

Creating the brain map

The researchers used a legacy collection of electron microscope images of the brain of an adult and juvenile nematode worm. Those images revealed individual brain cells or neurons, allowing the researchers to map the organisation of the worms' neural circuits, from the level of individual cells through to the large scale architecture of the entire brain.

Structure-function of the brain

The scientists identified known neural circuits and pathways within the brain such as a navigation neural circuit which an animal would use to follow smells and tastes to forage for food. Another circuit is thought to facilitate mechano-sensation, so it would feel its way as it wriggles through the soil - or sense if it is surrounded by bacteria.

Their theory is that information is processed in the worm's brain through a number of 'layers'. In fact, a similar layered architecture is found in the human brain. Information flow starts in sensory cells, which respond to the environment. For example, cells may sense bacteria but are they the right bacteria to feed on - do they smell like the 'right' bacteria? The answer requires information to be integrated from multiple senses before being sent to the command area of the brain for action.

Professor Cohen said: "The brain map reveals a very elegant structure to support information flow through a worm's brain and it is more sophisticated than the traditional view that simple animals follow a stimulus-response path.

"The map suggests a convergence of different neural circuits - and this allows the worm to integrate all of the different cues it is receiving through its sensory cells and to coordinate the response."

Variation in brain structure

During their study, the researchers were surprised to discover the extent of individual variation in the worms' brains.

C elegans is one of the most studied animals in biology. During the life of the worm, the way its cells divide and grow follows a strict blueprint which is observed across the entire species. But when it comes to the brain cells, there seemed to be a high degree of variation in the way the brain cells formed contacts with neighbouring cells to create neural circuits.

Using mathematical and computer models, the scientists were able to discern between those connections that are likely to form the 'core' circuit across a large population of animals, and those that appear to be variable between individuals.

Dr. Christopher Brittin, a former PhD student at the University of Leeds and first author on the paper said: "This work raises interesting questions about how even seemingly simple nervous systems are able to accommodate both core and individualized brain circuitry."

The scientists found that only around half the wiring in the worms' brains is similar - the other half showed variation.

Professor Cohen added: "This finding was really exciting for us. First, this suggests that worm brains have a lot more in common with the brains of higher animals than we knew or expected, and the lessons learned about worms can help us learn about brains more generally."

The variable connectivity may support individuality, redundancy and adaptability of brains as the animals face challenging, dangerous and ever-changing environments.


For further information, please contact David Lewis in the Press office at the University of Leeds: or 07710 013287


There is a image of the brain map that can be downloaded by following this link. Please credit: University of Leeds.

The caption is: The spatial organisation of the C. elegans brain is modular. Shown are different regions supporting different information processing pathways in the brain of a worm.

Download the paper from this link when the embargo lifts:

The University of Leeds

The University of Leeds is one of the largest higher education institutions in the UK, with more than 38,000 students from more than 150 different countries, and a member of the Russell Group of research-intensive universities. The University plays a significant role in the Turing, Rosalind Franklin and Royce Institutes.

We are a top ten university for research and impact power in the UK, according to the 2014 Research Excellence Framework, and are in the top 100 of the QS World University Rankings 2020.

The University was awarded a Gold rating by the Government's Teaching Excellence Framework in 2017, recognising its 'consistently outstanding' teaching and learning provision. Twenty-six of our academics have been awarded National Teaching Fellowships - more than any other institution in England, Northern Ireland and Wales - reflecting the excellence of our teaching.

Under embargo until 16.00 UK time/ 11.00 US Eastern time on Wednesday, 24 February

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