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Ancient Link in the Basement Membrane

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American Association for the Advancement of Science (AAAS)

Ancient Link in the Basement Membrane

image: This is the proposed chemical structure of the sHM crosslink. (Top) Schematic of the alpha1alpha2alpha1 collagen IV network illustrating the interaction between the NC1 domains of triple-helical protomers. (Bottom left) A space-filling model of the NC1 hexamer quaternary structure shows the location of the sHM crosslinks (white). The sulfilimine bond that constitutes the sHM crosslink connecting the side chains of Met93 and Hyl211 is shown for the alpha1NC1-alpha1NC1 dimer. The same bond connects Met93 and Hyl211 in the alpha2NC1-alpha2NC1 dimer. This image relates to an article that appeared in the Sept. 4 issue of Science, published by AAAS. The study, by Dr. R. Vanacore at Vanderbilt University in Nashville, Tenn., and colleagues, was titled, "A Sulfilimine Bond Identified in Collagen IV." view more 

Credit: Image courtesy of <i>Science</i>/AAAS


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