The determination of airflow characteristics in the human upper airway is crucial in investigating obstructive sleep apnea, particle sedimentation, drug delivery, and many biomedical problems. Currently?computational simulations have been used more and more in the upper airway related studies. A precondition to choose a correct flow model to obtain credible predictions in numerical simulations is to know the airflow characteristics in the upper airway. However, direct visualization of air flow patterns in in-vitro models with complex geometrical structures is a big challenge.
Professor Yaqi Huang's team in the Capital Medical University in Beijing, China, has developed a unique method and performed the first direct visualization of air flow in the in-vitro models built based on realistic anatomical structures of the upper airway. The paper entitled "Direct visualizations of air flow in the human upper airway using in-vitro models" was published in SCIENCE CHINA Life sciences recently.
The investigators constructed unique half-side transparent physical models of the upper airway for normal subjects (Figure 1). Using smoke-wire to trace the airflow on the green laser sheet background in the physical models, they captured the streamlines in the mid-sagittal plane of the pharyngeal airway using a high-speed camera. The results revealed that the airflow through the pharynx in both the mean-structure (Figure 1a) and the individual structure (Figure 1b) models was a laminar flow with vortexes but not a turbulent flow under normal inspiration. The flow field predicted numerically using the laminar model was consistent with the observations in the physical models.
From a comparison of the velocity fields predicted numerically using the half-side model (column 2 in Figure 2) and complete model (column 3 in Figure 2), one can fine that the speed range and flow patterns in both models are quite similar except for the slow flow in the boundary layer region of the flat wall in the half-side model. This confirms that it is reasonable to investigate the flow behaviors in the upper airway using the half-side model. The effects of the upper airway narrowing on pharyngeal resistance are also simulated and analyzed using numerical models in this study.
This research was funded by from the National Nature Science Foundation of China (Nos 31670959?81171422), the National Science and Technology Pillar Program of China (No, 2012BAI05B03), the Key Projects in Science and Technology Program of Beijing Municipal Education Commission, China (No. KZ201210025022), Beijing Postdoctoral Research Foundation (No. 2016ZZ-45), and Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application.
See the article:
Wu, H., Wang, M., Wang, J., An, Y., Wang, H., and Huang, Y. (2018). Direct visualizations of air flow in the human upper airway using in-vitro models. Sci China Life Sci 61, https://doi.org/10.1007/s11427-018-9373-y
Science China Life Sciences