BOSTON - Carbon monoxide (CO)--which is produced by cars and trucks, as well as fires and explosions--is a toxic, colorless, and odorless gas, and there are more than 50,000 admissions to US emergency rooms due to CO poisoning each year, with many cases involving damaged airways and lungs. Investigators at Massachusetts General Hospital (MGH) recently developed a phototherapy strategy that was highly effective for removing CO in rats and improving the animals' health.
"Whenever CO intoxication is associated with lung injury, current treatment with pure oxygen is ineffective and sometimes even dangerous. If the development of our technology for larger animals and humans will be successful, this may represent a unique alternative treatment for CO poisoned individuals with concurrent lung injury," said lead author Luca Zazzeron, MD, a clinical fellow in anesthesia at MGH.
The strategy relies on the knowledge that inhaled CO reduces the capacity of blood to carry oxygen by displacing oxygen from the blood's hemoglobin, and that visible light can break the molecular bond between CO and hemoglobin. As described in their Science Translational Medicine study, the researchers developed a device that combines phototherapy with a "membrane oxygenator"--an artificial membrane that allows oxygenation of the blood and removal of CO when blood is passed through it--and they tested the device in a rat model of CO poisoning, with and without lung injury.
Compared with ventilation with 100% oxygen, the addition of CO removal with phototherapy doubled the rate of CO elimination in CO-poisoned rats with normal lungs. In CO-poisoned rats with lung injury, this treatment increased the rate of CO removal by threefold compared with ventilation with 100% oxygen alone, and more animals that were treated in this way survived.
"Although additional studies are required, in the future, soldiers, firefighters, and civilians exposed to CO may benefit from early treatment with CO removal and phototherapy, in particular those individuals with concurrent lung injury," said Zazzeron.
About the Massachusetts General Hospital
Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH Research Institute conducts the largest hospital-based research program in the nation, with an annual research budget of more than $1 billion and comprises more than 8,500 researchers working across more than 30 institutes, centers and departments. In August 2019 the MGH was once again named #2 in the nation by U.S. News & World Report in its list of "America's Best Hospitals."
Science Translational Medicine