Prostate cancer is the most common form of cancer among Canadian men and the third leading cause of cancer death. Abdominal obesity appears to be associated with a greater risk of developing aggressive prostate cancer. This link was demonstrated in a study led by Professor Marie-Élise Parent of Institut national de la recherche scientifique (INRS) and published in the journal Cancer Causes & Control.
Over the years, several studies have shown that obesity is a major risk factor for prostate cancer. To further explore the link between disease incidence and body mass, the research team studied data from a survey conducted in Montréal between 2005 and 2012. Researchers observed that abdominal obesity was associated with an increased risk of aggressive cancer.
"Pinpointing the risk factors for aggressive cancer is a big step forward in health research because it's the hardest to treat," said Prof. Parent. "This data creates an opportunity to work preventively, by monitoring men with this risk factor more closely," she added.
Abdominal and general obesity
The actual distribution of body fat appears to be a significant factor in the development of the disease: the impact on a person's health can vary depending on whether the fat is concentrated around the abdomen or distributed throughout the body. According to Éric Vallières, a Université de Montréal student conducting his doctoral research at INRS and the study's main author, "Abdominal obesity causes hormonal and metabolic variations that can promote the growth of hormone-dependent cancer cells. Abdominal obesity is believed to be associated with a decrease in testosterone, as well as a state of chronic inflammation linked to the development of aggressive tumours."
General obesity did not show the same correlation as abdominal fat. This may result from a detection bias and possible biological effects. "In obese people, the protein used to detect prostate cancer at an early stage, prostate-specific antigen (PSA), is diluted in the blood," Mr. Vallières says. "This hemodilution makes cancer more difficult to detect."
The research team believes that studies on the timing of obesity exposure over a lifetime should be prioritized, and that a more in-depth analysis of body fat distribution could provide greater insight into the risks of developing prostate cancer.
About the study
The article "General and abdominal obesity trajectories across adulthood, and risk of prostate cancer: results from the PROtEuS study, Montreal, Canada," by Éric Vallières, Miceline Mésidor, Marie-Hélène Roy-Gagnon, Hugues Richard and Marie-Élise Parent, was published in Cancer Causes & Control in April. The study received funding from the Canadian Cancer Society, the Cancer Research Society, Fonds de recherche du Québec-Santé (FRQS), Ministère de l'Économie et de l'Innovation and the Canadian Institutes of Health Research (CIHR).
INRS is a university dedicated exclusively to graduate level research and training. Since its creation in 1969, INRS has played an active role in Québec's economic, social, and cultural development and is ranked first for research intensity in Québec and in Canada. INRS is made up of four interdisciplinary research and training centres in Québec City, Montréal, Laval, and Varennes, with expertise in strategic sectors: Eau Terre Environnement, Énergie Matériaux Télécommunications, Urbanisation Culture Société, and Armand-Frappier Santé Biotechnologie. The INRS community includes more than 1,500 students, postdoctoral fellows, faculty members, and staff.
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Cancer Causes & Control