video: Immunofluorescence imaging, (10 frames/s) of exposed dermis that was IV-injected with 100 μl of 10 mg/ml 155 kDa TRITC-dextran. Basal blood vessel leakage was recorded, while tissue was incubated with Ringer’s solution (saline). Immediately after, the exposed dermis was covered with Ringer's solution supplemented with 10 μg/ml of appropriate vascular endothelial growth factor A and imaging of the dextran leakage in identical field of dermis was repeated. This video relates to a paper that appeared in the Feb. 21, 2014, issue of Science, published by AAAS. The paper, by M.M. Martino at the Ecole Polytechnique Fédérale de Lausanne in Lausanne, Switzerland, and colleagues was titled, "Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing." view more
Credit: [Video courtesy of <i>Science</i>/AAAS]