image: The ABCD method specifically capitalizes on DNA-barcoded antibody sensing, where barcodes can be photocleaved and digitally detected without any amplification steps. In addition to mapping heterogeneity, the authors demonstrate its potential as a clinical tool to identify pathway responses to molecularly targeted drugs and to predict drug response using patient samples. This image relates to a paper that appeared in the January 15, 2014, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. A.V. Ullal at Massachusetts General Hospital in Boston, Mass., and colleagues was titled, "Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates." view more
Credit: Image courtesy of Ralph Weissleder