News Release

Researchers identify risk factors of advanced liver disease in cystic fibrosis patients

Children's Colorado researchers help to identify factors tied to a greater risk of developing advanced liver disease in cystic fibrosis patients

Peer-Reviewed Publication

Children's Hospital Colorado

Michael Narkewicz, MD

image: Michael Narkewicz, MD, is a pediatric gastroenterologist at Children's Hospital Colorado. He recently presented study results at the North American Cystic Fibrosis Conference. view more 

Credit: Children's Hospital Colorado

Aurora, Colo. (Nov. 12, 2018) - Children's Hospital Colorado (Children's Colorado) pediatric gastroenterologist, Michael Narkewicz, MD, recently shared results of the Prospective Study of Ultrasound to Predict Hepatic Cirrhosis in Cystic Fibrosis (PUSH), which sought to determine if liver ultrasounds could identify children and adolescents with cystic fibrosis who are at greater risk of developing advanced liver disease. The Cystic Fibrosis Liver Disease Network PUSH study is a multicenter prospective observational clinical trial that tested the hypothesis that a heterogeneous pattern (i.e., not totally uniform) on a liver ultrasound predicts the subsequent development of cirrhosis, late advanced stage of scarring (fibrosis) of the liver. Dr. Narkewicz presented the study results at the North American Cystic Fibrosis Conference after four years of research that was funded by the Cystic Fibrosis Foundation and The National Institute of Diabetes and Digestive and Kidney Diseases.

Advanced liver disease is a complication that affects about seven percent of all individuals with cystic fibrosis and is the third leading cause of death in cystic fibrosis. Primarily, this is a complication that affects children and adolescents, with 10 years of age marking the average age of diagnosis. To date, there is no test that can identify children at risk for developing advanced liver disease.

The team enrolled 744 children and adolescents with cystic fibrosis who did not have known advanced liver disease. All subjects underwent a research ultrasound of the liver that was scored by four independent study radiologists. Those with a heterogeneous ultrasound pattern of the liver and two matched controls with a normal pattern received follow-up ultrasounds every other year.

At the end of four years of follow-up, the team found that individuals with heterogeneous ultrasound patterns had a 9.3 times increased risk of developing advanced liver disease. 25% of the individuals with a heterogeneous pattern developed advanced liver disease within four years.

"This is the first study to identify a tool to classify a group of children and adolescents with cystic fibrosis who are at high risk for developing advanced liver disease," said Dr. Narkewicz. "This is an important discovery that provides an opportunity to continue testing interventions that might slow or stop that progression. This also might have relevance for screening in routine clinical care."

Dr. Narkewicz and his team are further refining the prediction model using lab tests and other innovative diagnostic tests that are part of the ongoing network studies. This sets up the possibility of designing trials for interventions to try to prevent the development of advanced liver disease in more cystic fibrosis patients.


About Children's Hospital Colorado

Children's Hospital Colorado is one of the nation's leading and most expansive pediatric healthcare systems with a mission to improve the health of children through patient care, education, research and advocacy. Founded in 1908 and recognized as a top ten children's hospital by U.S. News & World Report, Children's Colorado has established itself as a pioneer in the discovery of innovative and groundbreaking treatments that are shaping the future of pediatric healthcare worldwide. Children's Colorado offers a full spectrum of family-centered care at its urgent, emergency and specialty care locations throughout Colorado, including its location on the Anschutz Medical Campus, and across the region. Scheduled to open in spring 2019, the new Children's Hospital Colorado, Colorado Springs will be the first pediatric-only hospital in southern Colorado. For more information, visit, or connect with us on Facebook and Twitter.

Children's Hospital Colorado complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex.

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