image: The reactions involved in the FIND-IT assay to detect infection with the SARS-CoV-2 virus. When the Cas13 enzyme (bottom left) binds to its target RNA, it snips a molecule (orange and light blue ribbon) to release an activator (orange) that supercharges the Csm6 nuclease (right) to cleave and release fluorescent molecules that light up (green) and signal the presence of viral RNA. view more
Credit: Artwork courtesy of Margaret L. Liu, University of Chicago Pritzker School of Medicine
Journal
Nature Chemical Biology
Method of Research
Experimental study
Subject of Research
Human tissue samples
Article Title
Accelerated RNA detection using tandem CRISPR nucleases
Article Publication Date
5-Aug-2021