Stroke patients were almost twice as likely to be functionally independent—mobile and able to perform daily tasks—at 90 days post-stroke if they were treated by a specialized mobile stroke team that traveled to them to perform mechanical clot removal, compared to those who were transferred to a thrombectomy stroke center, according to research conducted within the Mount Sinai Health System and published today in Stroke, a journal of the American Stroke Association, a division of the American Heart Association.
The study examines results of a pilot program created by stroke specialists at Mount Sinai in New York City. Through this program, instead of transferring stroke patients to a specialized stroke center, a mobile interventional stroke team (MIST) traveled to the patient to perform endovascular thrombectomy—a surgical procedure used to remove large blood clots in patients with acute ischemic stroke. The MIST team includes a neuro-interventionist, an assistant, and a radiologic technologist. The trial focused on 226 patients who received endovascular thrombectomy at four hospitals within the Mount Sinai Health System between January 2017 and February 2020.
Medications to dissolve large blood clots in vessels in or leading to the brain are effective in about 15 to 20 percent of stroke cases. However, most patients with a large vessel blockage still require endovascular thrombectomy. Nearly 90 percent of strokes are ischemic strokes, caused by blood clots in an artery that blocks normal blood flow and oxygen leading to the brain. Since 2015, endovascular thrombectomy has been the standard of care for stroke therapy. Currently, the biggest barrier for stroke patients is timely access to this potentially life-saving procedure.
“Less than 50 percent of Americans have direct access to endovascular thrombectomy, with the other half needing to be transferred to a thrombectomy-capable hospital for treatment, often losing more than two hours of time to treatment,” said Johanna Fifi, MD, Associate Director of the Mount Sinai Cerebrovascular Center, Co-Director of Pediatric Cerebral Disorders, and Associate Professor of Neurosurgery, Neurology and Radiology at the Icahn School of Medicine at Mount Sinai and co-author of the study. “Every minute is precious in treating stroke, and getting to a center that offers thrombectomy is critically important. The MIST model addresses this loss of time and brain health by providing faster access to this surgical treatment.”
Researchers examined data from 226 patients who received endovascular thrombectomy at four hospitals within the Mount Sinai Health System (one is a certified comprehensive stroke center, and three are thrombectomy-capable stroke centers). Of those, 106 patients were treated by the MIST team, and 120 were treated by the current standard of care at hospitals without expertise in endovascular thrombectomy. Current standards are to treat patients with medications to dissolve the clot and then transfer the patient to a hospital with the expertise to perform endovascular thrombectomy. All patients in the analysis were functionally independent before having a stroke.
To assess outcomes, researchers used the modified Rankin Scale (mRS) and the National Institutes of Health Stroke Scale, two commonly used measures of the degree of disability or dependence in the daily activities of people who have suffered a stroke. They analyzed results of patients who were seen within six hours of stroke onset (early therapeutic window) and after six hours of stroke symptoms (late window).
For patients treated within the early window, the rate for a good outcome (mRS less than 2—mobile and can perform daily tasks) three months after the event was significantly higher in patients from the MIST group (54 percent) compared to the patients in the transferred group (28 percent). However, for patients treated in the late window, outcomes were similar, with 35 percent of patients in the MIST group having a good 90-day outcome, compared with 41 percent in the transferred group.
“Ischemic strokes often progress rapidly and can cause severe damage because as the brain is starved of blood and oxygen, and brain tissue dies quickly, resulting in serious long-term disabilities or death,” said Dr. Fifi. “Assessing stroke patients in the early window means that a greater number of fast-progressing strokes are identified and treated.”
Data for the MIST trial was collected prospectively, however, the analysis was conducted retrospectively. The MIST program continues as more institutions and cities implement the model.
About the Mount Sinai Health System
The Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai advances medicine and health through unrivaled education and translational research and discovery to deliver care that is the safest, highest-quality, most accessible and equitable, and the best value of any health system in the nation. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture ambulatory surgery centers; more than 415 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. The Mount Sinai Hospital is ranked on U.S. News & World Report's "Honor Roll" of the top 20 U.S. hospitals and is top in the nation by specialty: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. Mount Sinai Kravis Children's Hospital is ranked in U.S. News & World Report’s “Best Children’s Hospitals” among the country’s best in four out of 10 pediatric specialties. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools," aligned with a U.S. News & World Report "Honor Roll" Hospital, and No. 14 in the nation for National Institutes of Health funding. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. For more information, visit https://www.mountsinai.org or find Mount Sinai on Facebook, Twitter and YouTube.
Method of Research
Subject of Research
Mobile Interventional Stroke Teams Improve Outcomes in the Early Time Window for Large Vessel Occlusion Stroke
Article Publication Date