The use of legal drugs (tobacco and alcohol) may lead to the use of cannabis, a new study led by the University of Bristol and published in the journal Addiction has found. The study also found evidence that cannabis use may lead to smoking initiation, and opioid dependence could lead to increased alcohol consumption. Additionally, there might be shared risk factors that influence the use of multiple substances.
“Legal consumption of alcohol and tobacco may directly increase the level of illicit drug use. However, the relationships are complex. Consuming one drug does appear to increase the consumption of another, but it may also be the case that people have underlying risk factors which increase their chances of consuming both alcohol and tobacco and illicit drugs.”
The study found evidence for a possible gateway effect between 1) tobacco use and subsequent alcohol and cannabis use, 2) cannabis use and subsequent tobacco use, and 3) opioid dependence and subsequent alcohol consumption. It is possible that there may be bidirectional relationships – for example between tobacco and cannabis use – where cause and effect is operating in both directions. However, given that tobacco and alcohol use usually begin before other drug use, it is also possible that there may be shared risk factors – possibly a common genetic predisposition to substance use – underlying these relationships. Further examination of these specific relationships is required to determine the exact mechanisms behind these possible gateway effects.
Hazel Cheeseman, Deputy Chief Executive of Action on Smoking and Health commenting on the studies implications said:
“Tobacco and alcohol cause tremendous harm to society and these findings indicate that they may also increase the use of other drugs. Governments tend to take separate approaches to reducing the harm from legal and illegal drugs, but the long-promised Addictions Strategy provides an opportunity to look at the overlap between addictions and be more integrated.”
Many studies which have sought to understand the relationship between consuming different drugs rely on observed associations. The problem with relying on observed associations is that both types of drug use (legal and illegal) may be caused by a shared underlying risk factor, such as impulsiveness, and it is difficult to determine whether relationships are causal. To avoid this problem, the research team used a statistical approach called Mendelian randomisation.
Mendelian randomisation uses genetics to support stronger conclusions about possible causal relationships between an exposure (a potential cause) and outcome (a potential effect) that is less likely to be affected by a ‘confounder’ (a third variable that affects both the exposure and the outcome). In this study, researchers used known genetic variants that predispose people to use tobacco, alcohol, cannabis, cocaine or opioids and then looked at whether there might be causal relationships between both tobacco and alcohol and these illicit drugs. Using genetic variants as a proxy for an exposure reduces problems of confounding and allows stronger conclusions about whether an exposure truly causes and outcome – in this case whether use of one substance leads to the use of another.
‘Using Mendelian randomisation to explore the gateway hypothesis: Possible causal effects of smoking initiation and alcohol consumption on substance use outcomes’ by Reed ZE, Wootton RE, and Munafò MR in Addiction
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The paper is free to download for one month from the Wiley Online Library: https://onlinelibrary.wiley.com/doi/abs/10.1111/add.15673 or by contacting Jean O’Reilly, Editorial Manager, Addiction, firstname.lastname@example.org.
A short, animated introduction of the Mendelian randomisation technique is available on YouTube; see: https://www.youtube.com/watch?v=LoTgfGotaQ4
To speak with co-author Dr Zoe Reed, contact Joanne Fryer [Mon to Weds], email: email@example.com, mobile: +44 (0)7747 768805 or Caroline Clancy [Weds to Fri], email: firstname.lastname@example.org, mobile: +44 (0)7776 170238 in the University of Bristol Press Office
Full citation for article: Reed ZE, Wootton RE, and Munafò MR (2021) Using Mendelian randomisation to explore the gateway hypothesis: Possible causal effects of smoking initiation and alcohol consumption on substance use outcomes. Addiction: doi:10.1111/add.15673.
Funding: This work was supported in part by Public Health England, the UK Medical Research Council Integrative Epidemiology Unit at the University of Bristol (Grant ref: MC_UU_00011/7), and the National Institute for Health Research (NIHR) Biomedical Research Centre at the University Hospitals Bristol National Health Service Foundation Trust and the University of Bristol.
Addiction (www.addictionjournal.org) is a monthly international scientific journal publishing peer-reviewed research reports on alcohol, substances, tobacco, and gambling as well as editorials and other debate pieces. Owned by the Society for the Study of Addiction, it has been in continuous publication since 1884.
About the Tobacco and Alcohol Research Group (TARG)
TARG conduct research into the psychological and biological factors underlying health behaviours. We are part of the MRC Integrative Epidemiology Unit (MRC IEU) at the University of Bristol.
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The MRC Integrative Epidemiology Unit (IEU) is a research unit based at the University of Bristol with funding from the Medical Research Council. It uses genetics, population data and experimental interventions to look for the underlying causes of chronic disease.
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Using Mendelian randomisation to explore the gateway hypothesis: Possible causal effects of smoking initiation and alcohol consumption on substance use outcomes
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