News Release

Acta Pharmaceutica Sinica B Volume 11, Issue 10 publishes

Peer-Reviewed Publication

Compuscript Ltd

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Credit: APSB

In 2021 Acta Pharmaceutica Sinica B (APSB) is celebrating its 10th anniversary. The journal was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.

APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.

Articles of interest in this issue:


Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3 by Tian Lu, Yong Li, Wenchao Lu et al. ( The authors of this article obtained a selective TEAD3 inhibitor DC-TEAD3in03 that reduced the growth rate of zebrafish caudal fin through gel-based ABPP palmitoylation assay and follow-up structural optimization.


TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target by Shanshan Liu, Xiaoxi Lv, Xupeng Wei et al. ( Elevated TRIB3 expression in macrophages positively correlate with the development of pulmonary fibrosis. TRIB3 interaction with GSK-3β obstructs the ubiquitination and degradation of GSK-3β. Targeting TRIB3‒GSK-3β interaction reduces pulmonary fibrosis.


Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii by Liuying Mao, Baolong Jin, Lingli Chen et al. ( A Pacbio full-length transcriptome of Aconitum carmichaelii were publicly available. Twelve diterpene synthases were functional identified to responsible for atisine, napelline type diterpene alkaloids (DAs) and ent-13-epi-sandaracopimaradie biosynthesis, respectively.


Cancer-specific calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy by Dan Li, Yingli Wang, Chang Li et al. ( The authors of this paper developed cancer-specific calcium nanoregulator to enhance anti-metastasis combinational chemotherapy, which showed remarkable anti-tumor and anti-metastasis efficacy by targeting the homologous tumor cells, restraining the epithelial–mesenchymal transition, dissociating and depleting circulating tumor cell clusters.


Other articles published in the issue include:


Review Articles

Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development

Yuli Wang, Xingyan Zhang et al.


CRISPR-Cas9: A method for establishing rat models of drug metabolism and pharmacokinetics

Jian Lu, Jie Liu, Yuanqing Guo et al.


Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy

Minlin Jiang, Keyi Jia, Lei Wang et al.


Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases

Arun Upadhyay


Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease

Kai Zhang, Shiou Zhu, Jiamei Li et al.


Recent developments in the medicinal chemistry of single boron atom-containing compounds

Shu Song, Ping Gao, Lin Sun et al.


Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design

Qi Qiao, Xiong Liu, Ting Yang et al.



MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction

Le Zhang, Lei Zhang, Yue Guo et al.


Original Articles

PD0325901, an ERK inhibitor, enhances the efficacy of PD-1 inhibitor in non-small cell lung carcinoma

Min Luo, Yuhui Xia, Fang Wang et al.


Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR

Xiaojia Liu, Mingxiao Yin, Jingwen Dong et al.


3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing

Lina Xu, Lianhong Yin, Yan Qi et al.


Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment

Jianxiang Chen, Yiting Qiao, Guo Chen et al.


Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218

Po Hu, Hui Li, Wenzhuo Sun et al.


Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy

Jing Zhu, Meng Xin, Congcong Xu et al.


Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections

Liting Cheng, Miao-Miao Niu, Tong Yan et al.


Tumor microenvironments self-activated nanoscale metal-organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemotherapy

Yu Liang, Li Zhang, Chao Peng et al.


Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy

Hao Ren, Jiahui Yong, Qingqing Yang et al.


Cytosolic delivery of the immunological adjuvant Poly I:C and cytotoxic drug crystals via a carrier-free strategy significantly amplifies immune response

Xiaoqing Du, Yuqi Hou, Jia Huang et al.


Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence

Xiu Han, Xiang Xu, Ziheng Wu et al.


TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor

Tingting Peng, Yao Huang, Xiaoqian Feng et al.


Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin III to baccatin III

Hao Wang, Bo-Yong Zhang, Ting Gong et al.



Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity

Bin Lu, Jianpin Ye



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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit

Editorial Board:


APSB is available on ScienceDirect (


Submissions to APSB may be made using Editorial Manager® (


CiteScore: 12.5

Impact Factor: 11.614

JIF without self-citation: 10.746


ISSN 2211-3835

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