Comparison of a 5 F microtube-irrigated ablation catheter and a general ablation catheter in the treatment of resistant hypertension with renal denervation

Comparison of a 5 F Microtube-Irrigated Ablation Catheter and a General Ablation Catheter in the Treatment of Resistant Hypertension with Renal Denervation

In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2021.0023, Jun-Qing Gao, Hong Zhang, Ling-Yan Li and colleagues from Shanghai University of Traditional Chinese Medicine, Shanghai, China compare 5 F microtube-irrigated ablation catheters and general ablation catheters in the treatment of resistant hypertension with renal denervation.

The authors of this article assessed the effectiveness of catheter-based renal denervation for reducing blood pressure in patients with resistant hypertension using a 5F microtube-irrigated ablation catheter.

Sixty patients with resistant hypertension were divided into two groups: a microtube-irrigated ablation catheter group and a general ablation catheter group. We conducted 12-month follow-up of all patients and recorded clinical blood pressure, ambulatory blood pressure, medication use, and biochemistry test results in both groups at the baseline and at the 12-month follow-up.

All patients underwent renal denervation. At the 6-month follow-up, ambulatory blood pressure in the microtube-irrigated ablation catheter group was significantly lower than in the general ablation catheter group (systolic blood pressure 142.0 ± 14.4 mmHg vs. 150.8 ± 17.9 mmHg, P = 0.04; diastolic blood pressure 81.2 ± 7.0 mmHg vs. 87.6 ± 8.0 mmHg, P = 0.002). At the 12-month follow-up, the between-group difference in ambulatory blood pressure was not statistically significant. At the 12-month follow-up, the number of antihypertensive drugs and diuretics used in the microtube-irrigated ablation catheter group was less than in the general ablation catheter group (P = 0.043). There was no statistical difference between the two groups in the results of biochemistry tests and echocardiography.

The authors concluded that microtube-irrigated ablation catheter is more effective in treating hypertension than the general ablation catheter at the 6-month follow up and thus fewer antihypertensive drugs were used in the microtube-irrigated ablation catheter group than in the general ablation catheter group.  

Citation information: Comparison of a 5 F Microtube-Irrigated Ablation Catheter and a General Ablation Catheter in the Treatment of Resistant Hypertension with Renal Denervation, Jun-Qing Gao, Hong Zhang, Ling-Yan Li et al., Cardiovasc. Innov. App., 2021, https://doi.org/10.15212/CVIA.2021.0023

Keywords: Renal denervation; sympathetic nervous system; microtube-irrigated ablation catheter; resistant hypertension

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