Genetic study of heart defects and autism finds new causative genes

Researchers identified almost two dozen genes that contribute to heart defects by studying genetic data from people born with congenital heart disease or autism. Hongyu Zhao of Yale University and colleagues developed a new algorithm to analyze genetic data from related conditions, which they describe in a new paper publishing November 4^th in the journal PLOS Genetics.

Multiple diseases that start early in life appear to be linked to mutations in the same genes.  Recent research looking at de novo mutations—new mutations that pop up in children that were not present in the parents—has demonstrated a connection between congenital heart defects and autism. However, sequencing de novo mutations is expensive, so small studies of individual diseases have limited power to identify genes that increase a person's risk of the disease.

In the new study, researchers developed an algorithm called M-DATA (Multi-trait De novo mutation Association Test with Annotations) that combines sequencing data from people with related conditions to identify genes that contribute to disease. They applied the new method to genetic data from people with congenital heart disease or autism and successfully identified 23 genes for congenital heart disease, including 12 that were previously unknown.

The researchers conclude that M-DATA is more effective at identifying genes that increase a person's risk than analyses focusing on a single disease. This is because instead of analyzing a small number of genomes from affected individuals, M-DATA analyzes a larger number of combined genomes from multiple groups of people. The new method may help researchers identify previously unknown genes linked to disease and improve our understanding of the cause and potential treatment for different conditions.

Zhao adds, “By jointly analyzing de novo mutations from congenital heart disease (CHD) and autism, we identified novel genes that may play an important role in explaining the shared genetic etiology of CHD and autism.”

Yuhan Xie, the lead student of the research, says, “As a biostatistics student, it’s very motivating to find what could be meaningful to the patients and their families.”

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In your coverage, please use this URL to provide access to the freely available article in PLOS Genetics:

http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009849

Citation: Xie Y, Li M, Dong W, Jiang W, Zhao H (2021) M-DATA: A statistical approach to jointly analyzing de novo mutations for multiple traits. PLoS Genet 17(11): e1009849. https://doi.org/10.1371/journal.pgen.1009849

Author Countries: United States

Funding: This work was supported in part by NIH grant R03HD100883-01A1 (Y.X. and H.Z.) and R01GM134005-01A1 (W.J. and H.Z.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.