News Release

When and how to screen for colorectal cancer? New NCCN Patient Guideline explains latest timing and approaches

National Comprehensive Cancer Network shares new guide on effective tools for preventing and early detection of colorectal cancer and reducing cancer death; providing patients and caregivers free access to the latest expert recommendations at

Business Announcement

National Comprehensive Cancer Network

NCCN Guidelines for Patients; CRC Screening

image: NCCN Guidelines for Patients; CRC Screening now available free at view more 

Credit: NCCN

PLYMOUTH MEETING, PA [December 1, 2021] — The National Comprehensive Cancer Network (NCCN®) today announced the publication of new NCCN Guidelines for Patients®: Colorectal Cancer Screening. Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer in the United States, with an estimated 104,270 new cases of colon cancer and 43,230 new cases of rectal cancer in 2021, and an estimated 52,980 deaths this year.[1] Screening can reduce the rate of death by catching CRC at an earlier, more treatable stage, and can reduce overall cancer incidences by detecting and removing pre-cancerous polyps. This new, free guide for patients and caregivers breaks down the different ways screening can be done and explains the recommended timing according to the latest research.

“I was lucky that my colon cancer was diagnosed early enough to be successfully treated,” said Heather Matt, a four-year CRC survivor who was first diagnosed at age 35. “I want everyone to know about the importance of screening and how, when caught early, it may save you from having a very different outcome. A little discomfort today can ensure your tomorrow.”

Importance of screening

Accurate information about cancer screening is particularly important in light of the COVID-19 pandemic—which has seen reduced screening numbers projected to result in increased late-stage diagnoses. More on NCCN’s message that “Cancer Won’t Wait and Neither Should You” can be found at

“CRC screening has been shown to be one of the most effective prevention tools for a very common cancer that we know of,” said Reid M. Ness, MD, MPH, Associate Professor of Medicine, Vanderbilt-Ingram Cancer Center, and Chair of the NCCN Guidelines Panel for Colorectal Cancer Screening. “Studies show that we’ve reduced incidence rates by 40% since 1980, when screening was first recommended in the U.S. At the same time, it’s important to follow the latest evidence to make sure we’re applying screening to the people who can see the most benefit, while not putting anyone at unintended or inappropriate risk from diagnostic procedures and treatment.”

“Recommended screening significantly reduces cancer-related deaths; the numbers are astounding,” agreed panel Vice-Chair Xavier Llor, MD, PhD, Professor, Yale Cancer Center/Smilow Cancer Hospital. “This new patient guideline from NCCN offers a better understanding of the scientific research for the larger community. It provides a foundation for shared decision-making with patients and caregivers so we find the right screening fit for everyone.”

NCCN Guidelines for Patients are based on the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), which are determined by multidisciplinary teams of experts from across NCCN Member Institutions. NCCN Guidelines® are the recognized standard for clinical direction and policy in cancer care and the most thorough and frequently updated clinical practice guidelines available in any area of medicine. The patient versions are presented in easy-to-read language and format—with charts, images, and a glossary of medical terms—and were found to be among the most trustworthy options for cancer patients seeking information online, according to an independent study.

"For more than 15 years, our organization has worked with smart, relentless patients and caregivers who are looking for reliable information and answers about their treatment plans; many won't stop until they find them," said Anjee Davis, MPPA, President of Fight CRC. "We are proud sponsors of the NCCN Guidelines for Patients: CRC Screening because this is an important tool that empowers patients with the information they need to discuss their care with their doctors. We hope this resource empowers patients to choose the right screening option and get screened!"

Recently updated recommendations

In early 2021, the NCCN Guidelines for Colorectal Screening were updated to recommend screening begin possibly as young as 45-years-old for people at average risk, and includes additional recommendations for those with higher risk. Additionally, some follow-up screenings can safely be delayed for seven to ten years. The research is evolving rapidly and even primary care physicians may not be up-to-date on the latest expert consensus.

Drs. Llor and Ness both stressed that patients at any age who experience symptoms should be evaluated for colorectal cancer. Some of those symptoms include:

  • rectal bleeding;
  • changes in bowel habits;
  • persistent stomach pain;
  • fatigue;
  • and unexplained weight loss.

The panel also wanted to honor the significant contributions from longtime NCCN Guidelines Panel Chair, Dawn Provenzale, MD, of Duke Cancer Institute, who passed away earlier this year.

Free digital versions of the NCCN Guidelines for Patients: Colorectal Screening are available at and via the NCCN Patient Guides for Cancer App, thanks to funding from the NCCN Foundation®. The growing library of NCCN Guidelines for Patients includes nearly 60 frequently-updated books for patients and caregivers covering most major types of cancer, including colon and rectal cancers. There are additional guides covering cancer-related distress, nausea and vomiting, and survivorship (both healthy living & cancer-related late and long-term effects), plus special considerations for adolescents and young adults across all cancer types.

Learn more and help support these and other resources for people with cancer and their caregivers at

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About the National Comprehensive Cancer Network

The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to improving and facilitating quality, effective, equitable, and accessible cancer care so all patients can live better lives. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) provide transparent, evidence-based, expert consensus recommendations for cancer treatment, prevention, and supportive services; they are the recognized standard for clinical direction and policy in cancer management and the most thorough and frequently-updated clinical practice guidelines available in any area of medicine. The NCCN Guidelines for Patients® provide expert cancer treatment information to inform and empower patients and caregivers, through support from the NCCN Foundation®. NCCN also advances continuing education, global initiatives, policy, and research collaboration and publication in oncology. Visit for more information and follow NCCN on Facebook @NCCNorg, Instagram @NCCNorg, and Twitter @NCCN.

About the NCCN Foundation

The NCCN Foundation® was founded by the National Comprehensive Cancer Network® (NCCN®) to empower people with cancer and advance oncology innovation. The NCCN Foundation empowers people with cancer and their caregivers by delivering unbiased expert guidance from the world’s leading cancer experts through the library of NCCN Guidelines for Patients® and other patient education resources. The NCCN Foundation is also committed to advancing cancer treatment by funding the nation’s promising young investigators at the forefront of cancer research. For more information about the NCCN Foundation, visit

About Fight Colorectal Cancer (Fight CRC)

We fight to cure colorectal cancer and serve as relentless champions of hope for all affected by this disease through informed patient support, impactful policy change, and breakthrough research endeavors. As an organization dedicated to helping the community find trusted resources to make informed decisions about their health, we are proud to support this comprehensive resource.

[1] Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021 Jan;71(1):7-33. doi: 10.3322/caac.21654. Epub 2021 Jan 12. Erratum in: CA Cancer J Clin. 2021 Jul;71(4):359. PMID: 33433946.

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