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SIRT2: another important factor that determines the toxic effects and potential mechanisms of PM2.5

Peer-Reviewed Publication

Higher Education Press

SIRT2: another important factor that determines the toxic effects and potential mechanisms of PM2.5

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Credit: Higher Education Press Limited Company

Air pollutants comprise a complex mixture of airborne particles such as gases, liquids, and particulate matter (PM). Particulate matter 2.5 (PM2.5) refers to fine particles with aerodynamic equivalent diameter less than or equal to 2.5 μm in ambient air. It is one of the most harmful air pollutants that can be deposited in bronchi and alveoli through inhalation. Moreover, PM2.5 can even penetrate the air–blood barrier into the blood circulation. Epidemiological studies have shown a relationship between PM2.5 exposure and adverse health outcomes, including respiratory diseases, cardiovascular diseases, type 2 diabetes, and autoimmune diseases. Nevertheless, the mechanisms underlying PM2.5-induced airway inflammation remain largely unexplored. Fourth Military Medical University professor Qiong Wang and Heng Ma provide a novel mechanism underlying PM2.5-induced airway inflammation and bronchial hyperresponsiveness. This study entitled “Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2–p65 pathway" is published in Frontiers of Medicine on Nov. 2021.

In this study, PM2.5 exposure was found to trigger airway inflammation and bronchial hyperresponsiveness. Mechanistically, PM2.5 exposure lowered the expression and activity of SIRT2 in bronchial tissues. Notably, SIRT2 directly interacted with p65 and regulated the phosphorylation and acetylation activation of p65 to initiate the NF-κB signaling pathway and airway inflammation. Thereafter, the airway inflammation induced thickening in the bronchial smooth muscle layer and basement membrane layer, increased goblet cell proliferation and mucus secretion, tracheal stenosis, and bronchial hyperresponsiveness. Meanwhile, p65 phosphorylation and acetylation, airway inflammation, and bronchial hyperresponsiveness were deteriorated in SIRT2 knockout mice exposed to PM2.5. Importantly, we found that triptolide, an inhibitor of p65, significantly inhibited PM2.5-induced p65 phosphorylation and acetylation, thereby reducing airway inflammation and bronchial hyperresponsiveness.

This study demonstrated that the SIRT2-p65 signaling pathway is a novel mechanism responsible for PM2.5-induced organ damage, therefore providing a scientific basis and promising therapeutic and prevention strategies against PM2.5-induced toxicity.


About Higher Education Press

Founded in May 1954, Higher Education Press Limited Company (HEP), affiliated with the Ministry of Education, is one of the earliest institutions committed to educational publishing after the establishment of P.R.China in 1949. After striving for six decades, HEP has developed into a major comprehensive publisher, with products in various forms and at different levels. Both for import and export, HEP has been striving to fill in the gap of domestic and foreign markets and meet the demand of global customers by collaborating with more than 200 partners throughout the world and selling products and services in 32 languages globally. Now, HEP ranks among China's top publishers in terms of copyright export volume and the world's top 50 largest publishing enterprises in terms of comprehensive strength.

The Frontiers Journals series published by HEP includes 28 English academic journals, covering the largest academic fields in China at present. Among the series, 13 have been indexed by SCI, 6 by EI, 2 by MEDLINE, 1 by A&HCI. HEP's academic monographs have won about 300 different kinds of publishing funds and awards both at home and abroad.

About Frontiers of Medicine

Frontiers of Medicine is oriented to an international peer-reviewed journal of general medicine that captures the best science from the diverse medical disciplines and relevant fields encompassing different aspects of life sciences. The Editors-in-Chief are Academician Saijuan Chen, Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Academician Boli Zhang, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Academician Baofeng Yang; Harbin Medical University, Harbin, China; Academician Xiaoping Chen, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. The main topics include clinical medicine, basic medical sciences, epidemiology, translational research, traditional Chinese medicine, public health, and health policies. The journal has been indexed by SCI, MEDLINE, SCOPUS, Source Journals for Chinese Scientific and Technical Papers and Citations, CSCD, etc.


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