News Release

Those at highest risk for severe COVID-19 often least likely to get monoclonal antibodies

Peer-Reviewed Publication

Harvard T.H. Chan School of Public Health

Boston, MA – People over age 65 at the highest risk for severe COVID-19 have often been the least likely to receive monoclonal antibodies (mAbs)—a highly effective treatment for the disease—both across and within U.S. states, according to new research co-authored by researchers from Harvard T.H. Chan School of Public Health.

The analysis will be published online February 4, 2022 in JAMA.

“Monoclonal antibodies should first go to patients at the highest risk of death from COVID-19, but the opposite happened—the healthiest patients were the most likely to get treatment. Unfortunately, our federal and state system for distributing these drugs has failed our most vulnerable patients,” said Michael Barnett, assistant professor of health policy and management at Harvard Chan School and lead author of the study.

Monoclonal antibodies are very effective at treating mild to moderate COVID-19 infection among non-hospitalized patients. But during the pandemic, mAbs have been in short supply. Federal guidelines prioritize patients at higher risk of being hospitalized or dying from COVID-19, including older people and those with chronic conditions.

The researchers wanted to learn how the limited supply of mAb therapy was allocated to patients at highest risk for severe disease. They looked at data from more than 1.9 million Medicare beneficiaries who had been diagnosed with COVID-19 between November 2020 and August 2021, and compared rates of receiving mAbs by age, sex, race and ethnicity, region, and number of chronic conditions. 

They found that, among Medicare beneficiaries who weren’t hospitalized or who didn’t pass away within seven days of their diagnosis, only 7.2% received mAb therapy. The likelihood of receiving mAbs was higher among those with fewer chronic conditions—23.2% of those with no chronic conditions received mAbs, versus 6.3%, 6.0%, and 4.7% of those with 1-3, 4-5, and 6 or more chronic conditions, respectively. The researchers also found that Blacks were less likely to receive mAbs than whites—6.2% versus 7.4%.

In addition, there were significant differences among states when it came to mAb treatment. For example, Rhode Island and Louisiana administered mAbs to the highest proportion of non-hospitalized patients with COVID-19 (24.9% and 21.2%), while Alaska and Washington administered the lowest proportion (1.1% and 0.7%). Southern states had the highest rates of mAb therapy (10.6% of beneficiaries), while states in the West had the lowest rates (2.9%).

Speculating as to why mAb therapy often failed to reach the highest-risk COVID-19 patients, the researchers said it’s possible that higher-risk patients may have had difficulty navigating the multiple steps needed to receive mAbs, from receiving a timely diagnosis to referral and scheduling an infusion within 10 days. As for differences among states, they suggested that mAb supply may have been low or less used by clinicians in some regions of the U.S.

“We need new approaches to prevent these inequities from happening again with newer treatments on the horizon,” said Barnett.

Other Harvard Chan School co-authors included Ellen Meara, Arnold Epstein, and E. John Orav.

Funding for the study came from the National Institute on Aging (grant K23 AG058806) and the Agency for Healthcare Research and Quality (award U19 HS024075).

“Anti-SARS-CoV-2 Monoclonal Antibody Distribution to High-risk Medicare Beneficiaries, 2020-2021,” Caroline L. Behr, Karen E. Joynt Maddox, Ellen Meara, Arnold M. Epstein, E. John Orav, and Michael L. Barnett, JAMA, February 4, 2022, doi: 10.1001/jama.2022.1243

Visit the Harvard Chan School website for the latest newspress releases, and multimedia offerings.     


Harvard T.H. Chan School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and students, we work together to take innovative ideas from the laboratory to people’s lives—not only making scientific breakthroughs, but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty members at Harvard Chan School teach 1,000-plus full-time students from around the world and train thousands more through online and executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized as America’s oldest professional training program in public health.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.